PNLIPRP2 Antibody

Datasheet

Code	CSB-PA018264LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate All lanes: PNLIPRP2 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018264LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PNLIPRP2 Polyclonal antibody

Uniprot No.

P54317

Target Names

PNLIPRP2

Alternative Names

EC 3.1.1.3 antibody; Galactolipase antibody; LIPR2_HUMAN antibody; Pancreatic lipase-related protein 2 antibody; PL-RP2 antibody; PLRP2 antibody; Pnliprp2 antibody; Secretory glycoprotein GP 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pancreatic lipase-related protein 2 protein (305-460AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PNLIPRP2 Antibody (Product code: CSB-PA018264LA01HU) is Non-conjugated. For PNLIPRP2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA018264LB01HU	PNLIPRP2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018264LC01HU	PNLIPRP2 Antibody, FITC conjugated
Biotin	CSB-PA018264LD01HU	PNLIPRP2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane.

Gene References into Functions

findings show that endosomal lipases participate in lipid antigen presentation by processing lipid antigens and have a role in T cell immunity against mycobacteria PMID: 27662254
The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 PMID: 26494624
Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. PMID: 23732775
BSSL and PLRP2 hydrolyzed triglycerides (TG) to free FA and glycerol. PMID: 21865348
Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns PMID: 21652702
localization of PLRP2 in endosomes of monocytes PMID: 21554982
Investigation of the substrate specificity of purified recombinant pancreatic lipase-related protein 2 reveals that its physiological role is digestion of galactolipids, the main plant lipids present in the vegetables which are a part of the human diet. PMID: 15287741
Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both pancreatic lipase and PLRP2 than the controls subjects. PMID: 16887271
finding that the inhibition of nonproteolyzed rHPLRP2 by tetrahydrolipstatin and diethyl-p-nitrophenyl phosphate does not involve any bile salt requirements suggests that the rHPLRP2 lid adopts an open conformation in aqueous media. PMID: 17401110
Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2 PMID: 18702514
The pancreatic lipase related protein 2 is required for lipid-dependent cytotoxicity mediated by cytotoxic T lymphocytes. PMID: 19548271

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Subcellular Location

Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection.

Protein Families

AB hydrolase superfamily, Lipase family

Tissue Specificity

Pancreas.

Database Links

HGNC: 9157

OMIM: 604423

KEGG: hsa:5408

UniGene: Hs.423598

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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