PNLIPRP2 Antibody

Code CSB-PA018264LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate
    All lanes: PNLIPRP2 antibody at 3µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 52 kDa
    Observed band size: 52 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018264LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PNLIPRP2 Polyclonal antibody
Uniprot No.
Target Names
PNLIPRP2
Alternative Names
EC 3.1.1.3 antibody; Galactolipase antibody; LIPR2_HUMAN antibody; Pancreatic lipase-related protein 2 antibody; PL-RP2 antibody; PLRP2 antibody; Pnliprp2 antibody; Secretory glycoprotein GP 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pancreatic lipase-related protein 2 protein (305-460AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PNLIPRP2 Antibody (Product code: CSB-PA018264LA01HU) is Non-conjugated. For PNLIPRP2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA018264LB01HU PNLIPRP2 Antibody, HRP conjugated ELISA
FITC CSB-PA018264LC01HU PNLIPRP2 Antibody, FITC conjugated
Biotin CSB-PA018264LD01HU PNLIPRP2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane.
Gene References into Functions
  1. findings show that endosomal lipases participate in lipid antigen presentation by processing lipid antigens and have a role in T cell immunity against mycobacteria PMID: 27662254
  2. The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 PMID: 26494624
  3. Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. PMID: 23732775
  4. BSSL and PLRP2 hydrolyzed triglycerides (TG) to free FA and glycerol. PMID: 21865348
  5. Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns PMID: 21652702
  6. localization of PLRP2 in endosomes of monocytes PMID: 21554982
  7. Investigation of the substrate specificity of purified recombinant pancreatic lipase-related protein 2 reveals that its physiological role is digestion of galactolipids, the main plant lipids present in the vegetables which are a part of the human diet. PMID: 15287741
  8. Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both pancreatic lipase and PLRP2 than the controls subjects. PMID: 16887271
  9. finding that the inhibition of nonproteolyzed rHPLRP2 by tetrahydrolipstatin and diethyl-p-nitrophenyl phosphate does not involve any bile salt requirements suggests that the rHPLRP2 lid adopts an open conformation in aqueous media. PMID: 17401110
  10. Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2 PMID: 18702514
  11. The pancreatic lipase related protein 2 is required for lipid-dependent cytotoxicity mediated by cytotoxic T lymphocytes. PMID: 19548271

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Subcellular Location
Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection.
Protein Families
AB hydrolase superfamily, Lipase family
Tissue Specificity
Pancreas.
Database Links

HGNC: 9157

OMIM: 604423

KEGG: hsa:5408

UniGene: Hs.423598

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