POLR2B Antibody

Code CSB-PA018328GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
POLR2B
Alternative Names
POLR2B antibody; DNA-directed RNA polymerase II subunit RPB2 antibody; EC 2.7.7.6 antibody; DNA-directed RNA polymerase II 140 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit B antibody; RNA polymerase II subunit 2 antibody; RNA polymerase II subunit B2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human POLR2B-Specific
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template.
Gene References into Functions
  1. Studies indicate transcription of many genes, is regulated after the initiation step, by pausing of RNA polymerase II during elongation through the promoter-proximal region. PMID: 21081187
  2. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation PMID: 12050112
  3. The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of magnesium and is required for both for the polymerization and cleavage reactions. PMID: 15886393
  4. the human Maf1 protein negatively regulates transcription by all three nuclear Pols, Pol I, Pol II and Pol III PMID: 17499043
Subcellular Location
Nucleus.
Protein Families
RNA polymerase beta chain family
Database Links

HGNC: 9188

OMIM: 180661

KEGG: hsa:5431

STRING: 9606.ENSP00000312735

UniGene: Hs.602757

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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