PROC Antibody

1. The fusion protein recapitulates the functional and structural properties of the thrombin-thrombomodulin complex, prolongs the clotting time by generating pharmacological quantities of activated protein C and effectively diagnoses protein C deficiency in human plasma. PMID: 28294177
2. Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women. PMID: 29363996
3. Laboratory tests and direct sequencing of PROC and SERPINC1 were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in SERPINC1 and a short deletion variant c.572_574delAGA in PROC. PMID: 28861852
4. Patients with rheumatoid arthritis, polymyositis, systemic lupus erythematosus and ankylosing spondylitis showed higher serum levels of than healthy control individuals. PMID: 29303701
5. Using protein C-factor VII chimera demonstrate that APC light chain amino acid residues outside the EPCR-binding site enable cytoprotective PAR1 signaling. PMID: 28834159
6. We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC. PMID: 28405673
7. Developed functional protein S assays that measure both the activated protein C- and TFPI-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation. PMID: 28211163
8. Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer. PMID: 28376316
9. Genetically higher protein C was associated with a lower risk of ischaemic heart disease. PMID: 27882376
10. EPCR occupancy recruits G-protein coupled receptor kinase 5, thereby inducing beta-arrestin-2 biased PAR1 signaling by both APC and thrombin. In PMID: 27561318
11. A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency PMID: 28111891
12. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. PMID: 28468828
13. Both probands had hereditary protein C deficiencies, for which their parents were all carriers. PMID: 28186585
14. Variants influencing circulating protein C levels in the CELSR2-PSRC1-SORT1 region may indicate a novel genetic link between lipoprotein metabolism and hemostasis. PMID: 28082259
15. These findings suggest that the anti-inflammatory function of APC at therapeutic concentrations may include the inhibition of NETosis in an EPCR-, PAR3-, and Mac-1-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC in disease states including sepsis. PMID: 28408624
16. Collectively, these data depict a pivotal role for AMPK signaling in inhibiting ER stress responses via the activation of APC during MGO-induced cardiomyocyte apoptosis. Thus, APC may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy. PMID: 27794481
17. An activation-resistant homozygous protein C R229W mutation was linked to perinatal intracranial bleeding and delayed onset of thrombosis. PMID: 27172833
18. Structural and functional studies of novel heterozygous mutations in the PROC gene confirmed that the mutations were pathogenetic in two Chinese families with types I and II protein C deficiency. PMID: 27517348
19. The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROC is 85.6 (95% CI, 13.0-448.9; P = 2.0 x 10- 5. PMID: 28174134
20. Study detected a statistically significant positive correlation between expanded disability status scale scores and thrombomodulin levels (p<0.01) and a 10% positive correlation between expanded disability status scale scores and APC levels in multiple sclerosis patients PMID: 27456888
21. Low protein C expression is associated with diabetes mellitus. PMID: 27345772
22. Genetic variants in thrombomodulin and endothelial protein C receptor genes are additively associated with mortality in acute respiratory distress syndrome in European ancestry PMID: 27215212
23. Protein C and TAFI are concurrently activated in a thrombomoulin-dependent manner and do not compete for the thrombin-TM complex, raising the possibility that they interact with distinct activation complexes. PMID: 26663133
24. We herewith present the first case of fetal ventriculomegaly and neonatal stroke associated with heterozygous PROC mutation. PMID: 26250584
25. Elevated levels of circulating microparticles can play a role in carriers of mild and severe inherited thrombophilia resulting from protein C deficiency. PMID: 26354831
26. deficiency associated with venous thromboembolism in pregnancy PMID: 25586317
27. ApoER2 contributes cooperatively with endothelial cell protein C receptor and protease activated receptor 1 to APC-initiated endothelial antiapoptotic and barrier protective signaling. PMID: 26800564
28. Results show that free activated protein C binds to membrane EPCR in ovarian cancer cells inducing cell migration via MEK-ERK and Rho-GTPase pathways. The cancer cells become highly aggressive, and secondary nodules develop because of fibrin inhibition. PMID: 26082331
29. Low levels of protein C during pregnancy were not associated with adverse pregnancy outcome. PMID: 25879167
30. Report activation of protein C and down-regulation of EPCR in trophobolasts stimulated with TNF-alpha. PMID: 25667200
31. levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury PMID: 25790110
32. We conclude that the Cohn process significantly influences the anticoagulant activity of PC. Compared to the antigen, PC lost greater than 80% of its anticoagulant activity, but retained its amidolytic activity, during the Cohn process. PMID: 25730025
33. Data show the molecular model of the complex of activated protein C (APC) with alphaVbeta3 integrin obtained by protein-protein docking approach. PMID: 24251463
34. Our findings identify PROC on 2q14 as a novel candidate for childhood asthma PMID: 25643747
35. Protein C is activated during in vitro thrombolysis. PMID: 26552309
36. Results provide evidence that APC selectively inhibits proliferation and the inflammatory signaling pathways of rheumatoid synovial fibroblasts. PMID: 24096826
37. High avidity anti-protein C antibodies by provide marker for a severe thrombotic phenotype in antiphospholipid syndrome. PMID: 25196808
38. A single measurement of protein C was able to identify severe coagulopathy early in the course of sepsis. PMID: 24410881
39. Suggest that PC deficiency is an independent predictor for the progression of critical limb ischemia. PMID: 25115555
40. Hereditary protein C deficiency in a family with venous thrombosis was associated with two missense mutations in the PROC gene. PMID: 25748729
41. Heterozygous F139V mutations caused mild reduction of protein C function, which might be the reason for survival of compound heterozygous or homozygous protein C deficiency adults carrying these mutations. PMID: 24911457
42. A novel PC mutation in a healthy subject results in type II PC deficiency as diagnosed by commercial kits. PMID: 25651845
43. Dialysis patients who are carriers of the AG/GG genotypes of the PROC rs1799809 had a 1.2-fold increased 5-year all-cause mortality risk. PMID: 24816905
44. The study reports effects of the prothrombin Yukuhashi mutation on thrombomodulin-protein C anticoagulant system. PMID: 25149909
45. observed increased APC resistance in carriers of fibrinogen gamma gene (FGG) haplotype 2, which is associated with reduced levels of the alternatively spliced fibrinogen gamma' chain. We then studied the effects of fibrinogen and its gamma' chain on APC resistance. PMID: 24951429
46. Although platelet fVa shows slightly superior resistance to aPC's effects compared to plasma fVa, neither fVa is sufficiently cleaved in simulations of acute traumatic coagulopathy or pharmacologically-delivered aPC to diminish coagulation parameters. PMID: 24921658
47. The inflammation-induced activation of the protein C pathway provides negative feedback inhibition of coagulation and exerts coagulation-independent anti-inflammatory and cytoprotective effects. PMID: 24759138
48. Dysfunction of protein C in Japanese and Chinese in this review is significantly associated with increased risk for venous thromboembolism. PMID: 24233386
49. The PROC TAA haplotype was associated with a high protein C level and increased risk of venous thrombosis. PMID: 24158116
50. Decreased APC levels in patients with type 2 diabetes may serve as a biomarker to indicate the early development of diabetic nephropathy. PMID: 24660539

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HGNC: 9451

OMIM: 176860

KEGG: hsa:5624

STRING: 9606.ENSP00000234071

UniGene: Hs.224698