PRODH Antibody

1. PRODH1-mediated proline metabolism promotes pancreatic ductal adenocarcinoma growth. PMID: 28685754
2. Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations. We find that L-proline is a GABA-mimetic and can act at multiple GABA-ergic targets PMID: 27705802
3. PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells. PMID: 28942439
4. this study shows that PRODH plays a causative role in DNA damage-induced senescence through the enzymatic generation of reactive oxygen species PMID: 28264926
5. the frequency of a recurrent small 22q11.2 deletion encompassing PRODH and the neighboring DGCR6 gene in three case-control studies, was studied. PMID: 26978485
6. The findings support a major role for the PRODH 757TT, 1766GG, and 1852AA genotypes alone and in combination for schizophrenia susceptibility. PMID: 26436492
7. Thirty-five percent of the subjects were hyperprolinemic, allele carriers of PRODH rs450046 had a lower full-scale intelligence compared to T allele carriers PMID: 26068888
8. GR and KLF15 physically interact via low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15. PMID: 26088140
9. results suggest that PRODH and COMT may interact to contribute to the ASD phenotype in individuals with VCFS PMID: 25325218
10. Functional COMT, but not PRODH, variant affects IQ and executive functions in 22q11.2DS subjects during neurodevelopment with a maximal effect at adulthood PMID: 24853458
11. Data indicate that a functional proline dehydrogenase (PRODH) variant associated with schizophrenia that may have a neurochemical impact, altering brain function, but is not responsible for the cortical reductions found in the disorder. PMID: 24498354
12. The current study demonstrates that sensory gating impairments that are typical of schizophrenia are found in 22q11.2DS subjects. Our results further suggest that COMT and PRODH genetic variations contribute to sensory gating. PMID: 23910792
13. PRODH, but not PRODH2, expression is under the control of p53 family members, specifically p53 and p73. PMID: 23861960
14. Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH. PMID: 24218577
15. distinct molecular alterations of the PRODH gene result in abnormal proline levels. PMID: 23462603
16. results provide evidence that PRODH is essential in proline protection against hydrogen peroxide-mediated cell death and that proline/PRODH helps activate Akt in cancer cells PMID: 22796327
17. There is no association between proline dehydrogenase (oxidase) 1 polymorphisms and schizophrenia in Korean population PMID: 21960278
18. For a number of genes affected by de novo copy number variants CNVs in autism (CNTNAP2, ZNF214, ARID1B, Proline Dehydrogenase), reduced transcript expression may be a mechanism of pathogenesis during neurodevelopment. PMID: 21448237
19. miR-23b, by targeting proline oxidase, could function as an oncogene. PMID: 20562915
20. POX is critical in the cellular response to the noxious effects of oxLDL by activating protective autophagy. PMID: 19942609
21. Proline oxidase induces apoptosis in tumor cells PMID: 12514185
22. A complete homozygous PRODH deletion has been identified in a child with type I hyperprolinemia with severe neurological manifestations. PMID: 12525555
23. Genetic analysis of PRODH reveals no association with schizophrenia. PMID: 12815738
24. Finding supports a role for the PRODH locus in schizophrenia. PMID: 15274030
25. Results suggest that the molecular basis for increased plasma proline levels in schizophrenic subjects carrying the missense mutation Leu441Pro is due to decreased stability of human PRODH2. PMID: 15449943
26. No association was found between common PRODH polymorphisms and any of the psychotic disorders. Five rare PRODH alterations (including a complete PRODH deletion and four missense substitutions) were associated with hyperprolinemia. PMID: 15494707
27. severe hyperprolinemia (>800 microM) occurs in individuals with large deletions and/or PRODH missense mutations PMID: 15662599
28. proline oxidase mediates apoptosis through the generation of proline-dependent ROS, which then mobilize calcium and activate calcineurin PMID: 15914462
29. proline oxidase may modulate apoptosis signals induced by p53 or other anti-cancer agents and enhance apoptosis in stress situations PMID: 16619034
30. this meta-analysis did not find statistically significant evidence for association between RGS4 and PRODH and schizophrenia on the basis of either allelic or genotypic analysis. PMID: 16791139
31. In the presence of proline, high POX activity is sufficient to induce mitochondria-mediated apoptosis. PMID: 16874462
32. Analysis of the PRODH gene coding sequence variations,predicted that POX residual activity results into HPI, whereas residual activity in the 30-50% range is associated either with normal plasma proline levels or with mild-to-moderate hyperprolinemia. PMID: 17135275
33. Patients with biallelic PRODH alterations resulting in severely impaired proline oxidase activity had an early onset and severe neurological features. PMID: 17412540
34. we found evidence for COMT and PRODH epistasis: in patients with a COMT Val allele (rs4680) and with one or two mutated PRODH alleles, we observed increased WM density in the left inferior frontal lobe. PMID: 17504246
35. Molecular genetic analysis of COMT, PRODH and BDNF genes showed no significant effects of any variants on schizotypal components or factors of SPQ after correction for multiple testing. PMID: 17604122
36. In conjunction with the chromosomal location of PRODH, study findings suggest a potential involvement of this gene in the 22q11-associated cognitive, psychiatric and behavioral phenotypes. PMID: 18163391
37. Four Italian children with Type I hyperprolinemia presenting epilepsy, mental retardation, and behavioral disorders for PRODH gene mutations were screened, and a genotype-phenotype correlation was attempted. PMID: 18197084
38. Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers PMID: 18794809
39. A family-based sample showed functional polymorphisms in POX are associated with schizophrenia, with protective and risk alleles having opposite effects on POX activity. PMID: 18989458
40. Kinetic studies of the structural determinants of PRODH substrate specificity focus on how the enzyme discriminates between two closely related molecules, proline and hydroxyproline. PMID: 19140736
41. We assessed the relationship between these high-risk PRODH polymorphisms and schizophrenia-related endophenotypes PMID: 19232576
42. Glucose deprivation increased intracellular proline levels, and expression of POX activated the pentose phosphate pathway. PMID: 19415679
43. POX is a mitochondrial tumor suppressor and a potential target for cancer therapy. PMID: 19654292

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HGNC: 9453

OMIM: 181500

KEGG: hsa:5625

STRING: 9606.ENSP00000349577

UniGene: Hs.517352