PSMB7 Antibody

Datasheet

Code	CSB-PA01345A0Rb
Size	US$166
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Image	Western blot All lanes: Proteasome subunit beta type-7 antibody at 2μg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 30, 16 kDa Observed band size: 30 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA01345A0Rb at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA01345A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA01345A0Rb at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PSMB7 Polyclonal antibody

Uniprot No.

Q99436

Target Names

PSMB7

Alternative Names

Macropain chain Z antibody; Multicatalytic endopeptidase complex chain Z antibody; Proteasome (prosome macropain) subunit beta type 7 antibody; Proteasome beta 7 subunit antibody; Proteasome catalytic subunit 2 antibody; Proteasome subunit alpha antibody; Proteasome subunit beta 7 antibody; Proteasome subunit beta type-7 antibody; Proteasome subunit Z antibody; PSB7_HUMAN antibody; PSMB7 antibody; PUP1 antibody; Z antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Proteasome subunit beta type-7 protein (44-275AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PSMB7 Antibody (Product code: CSB-PA01345A0Rb) is Non-conjugated. For PSMB7 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA01345B0Rb	PSMB7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA01345C0Rb	PSMB7 Antibody, FITC conjugated
Biotin	CSB-PA01345D0Rb	PSMB7 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.

Gene References into Functions

Studied the associations of Protein Z (PROZ G79A) and Endothelin-1 (EDN1 G5665T) polymorphisms with the clinical features of sickle cell disease (SCD) in a cohort of Egyptian children with SCD. PMID: 28548215
reduced protein levels in patients with rheumatoid arthritis in association with disease progression PMID: 21713324
high PSMB7 expression is associated with anthracycline resistance in breast cancer. PMID: 20010949
Low protein Z levels but not protein Z gene G79A polymorphism are a risk factor for ischemic stroke. PMID: 18378283
A previously unreported sporadic missense mutation within exon 8 is described in a patient with very low protein Z levels. PMID: 18462727
PSB7, PRDX1, and SRP9 up-regulation as candidate biomarkers of colon cancer is discovered PMID: 18549262
ZPI functions like other serpins to regulate the activity of FXa but in a manner uniquely dependent on protein Z, procoagulant membranes, and pH PMID: 18768472
we have identified and characterized a new phosphorylated isoform of the human 20S proteasome b7 subunit and showed its differential expression in tumor vs. normal cell lines PMID: 19645816

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Peptidase T1B family

Tissue Specificity

Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues.

Database Links

HGNC: 9544

OMIM: 604030

KEGG: hsa:5695

STRING: 9606.ENSP00000259457

UniGene: Hs.213470

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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