PSMD3 Antibody

Code CSB-PA247793
Size US$297
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  • Western blot analysis of extracts from K562 cells, using PSMD3 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PSMD3 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PSMD3 Polyclonal antibody
Uniprot No.
Target Names
PSMD3
Alternative Names
26S proteasome non ATPase regulatory subunit 3 antibody; 26S proteasome non-ATPase regulatory subunit 3 antibody; 26S proteasome regulatory subunit RPN3 antibody; 26S proteasome regulatory subunit S3 antibody; OTTHUMP00000164347 antibody; P58 antibody; Proteasome (prosome, macropain) 26S subunit non ATPase 3 antibody; Proteasome subunit p58 antibody; PSMD3 antibody; PSMD3_HUMAN antibody; RPN3 antibody; S3 antibody; Tissue specific transplantation antigen 2 antibody; TSTA2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human PSMD3.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Gene References into Functions
  1. this study shows that haplotypes consisting of single nucleotide polymorphisms harboring PSMD3, CSF3 and MED24 genes are associated with asthma in Slovenian patients PMID: 27163155
  2. A strong association between genetic variant rs2305482 in PSMD3 on chromosome 17 and IFN-induced neutropenia. PMID: 25515861
  3. HNF1A gene was associated with C-reactive protein, and the region including PSMD3 and CSF3 genes was associated with white blood cell count. PMID: 22788528
  4. Our study suggests that PSMD3 variants are associated with insulin resistance in populations of different ancestries and that these relationships may also be modified by dietary factors. PMID: 23303871
  5. Study identified significantly white blood cell count (WBC) level associated SNPs of three separate genes GSDMA, MED24, and PSMD3 in European continent (EA) subjects. PMID: 22037903
  6. The significant contribution of PSMD3-CSF3 and PLCB4 loci to the regulation of neutrophil count, is demonstrated. PMID: 20172861

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Protein Families
Proteasome subunit S3 family
Database Links

HGNC: 9560

OMIM: 617676

KEGG: hsa:5709

STRING: 9606.ENSP00000264639

UniGene: Hs.12970

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