PTPN4 Antibody

Datasheet

Code	CSB-PA019041ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA019041ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA019041ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PTPN4 Polyclonal antibody

Uniprot No.

P29074

Target Names

PTPN4

Alternative Names

MEG antibody; megakaryocyte phosphatase antibody; megakaryocyte protein-tyrosine phosphatase antibody; Protein tyrosine phosphatase MEG1 antibody; Protein tyrosine phosphatase; megakaryocyte antibody; protein tyrosine phosphatase; non-receptor type 4 (megakaryocyte) antibody; Protein-tyrosine phosphatase MEG1 antibody; PTN4 antibody; PTN4_HUMAN antibody; PTPase MEG1 antibody; PTPase-MEG1 antibody; PTPMEG antibody; PTPMEG1 antibody; Ptpn4 antibody; Tyrosine protein phosphatase non receptor type 4 antibody; Tyrosine-protein phosphatase non-receptor type 4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Tyrosine-protein phosphatase non-receptor type 4 protein (1-240AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton.

Gene References into Functions

Binding assays confirmed that three (Cyto8-mtxd-1, Cyto8-mtxk-4 and Cyto8-mtxd-1k-4) out of the five designed peptides exhibit moderately or considerably increased affinity as compared to the native peptide Cyto8-RETEV PMID: 27923202
the p38gamma.PTPN4 interaction promotes cellular signaling, preventing cell death induction. PMID: 27246854
Deletion of PTPN4 has been reported in monozygotic twins with a Rett syndrome-like phenotype. PMID: 25424712
The physiologically active PTPN4 two-domain (the PDZ and the phosphatase domains) adopts a predominant compact conformation in solution. PDZ ligand binding restores the catalytic competence of PTPN4 disrupting the transient interdomain communication. PMID: 25158884
These findings suggest that PTPN4 negatively regulates cell proliferation and motility through dephosphorylation of CrkI. PMID: 23666597
PTPN4 is dispensable for T cell development and/or T cell effector functions. PMID: 18614237

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Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm.

Protein Families

Protein-tyrosine phosphatase family, Non-receptor class subfamily

Database Links

HGNC: 9656

OMIM: 176878

KEGG: hsa:5775

STRING: 9606.ENSP00000263708

UniGene: Hs.469809

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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