PTPN4 Antibody

Code CSB-PA019041ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA019041ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA019041ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PTPN4 Polyclonal antibody
Uniprot No.
Target Names
PTPN4
Alternative Names
MEG antibody; megakaryocyte phosphatase antibody; megakaryocyte protein-tyrosine phosphatase antibody; Protein tyrosine phosphatase MEG1 antibody; Protein tyrosine phosphatase; megakaryocyte antibody; protein tyrosine phosphatase; non-receptor type 4 (megakaryocyte) antibody; Protein-tyrosine phosphatase MEG1 antibody; PTN4 antibody; PTN4_HUMAN antibody; PTPase MEG1 antibody; PTPase-MEG1 antibody; PTPMEG antibody; PTPMEG1 antibody; Ptpn4 antibody; Tyrosine protein phosphatase non receptor type 4 antibody; Tyrosine-protein phosphatase non-receptor type 4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tyrosine-protein phosphatase non-receptor type 4 protein (1-240AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton.
Gene References into Functions
  1. Binding assays confirmed that three (Cyto8-mtxd-1, Cyto8-mtxk-4 and Cyto8-mtxd-1k-4) out of the five designed peptides exhibit moderately or considerably increased affinity as compared to the native peptide Cyto8-RETEV PMID: 27923202
  2. the p38gamma.PTPN4 interaction promotes cellular signaling, preventing cell death induction. PMID: 27246854
  3. Deletion of PTPN4 has been reported in monozygotic twins with a Rett syndrome-like phenotype. PMID: 25424712
  4. The physiologically active PTPN4 two-domain (the PDZ and the phosphatase domains) adopts a predominant compact conformation in solution. PDZ ligand binding restores the catalytic competence of PTPN4 disrupting the transient interdomain communication. PMID: 25158884
  5. These findings suggest that PTPN4 negatively regulates cell proliferation and motility through dephosphorylation of CrkI. PMID: 23666597
  6. PTPN4 is dispensable for T cell development and/or T cell effector functions. PMID: 18614237

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Subcellular Location
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class subfamily
Database Links

HGNC: 9656

OMIM: 176878

KEGG: hsa:5775

STRING: 9606.ENSP00000263708

UniGene: Hs.469809

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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