PTPRM Antibody

Datasheet

Code	CSB-PA166109
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA166109(PTPRM Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA166109(PTPRM Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P28827

Target Names

PTPRM

Alternative Names

tibody; hR PTPu antibody; Protein tyrosine phosphatase mu antibody; Protein tyrosine phosphatase mu precursor antibody; Protein tyrosine phosphatase receptor type M antibody; Protein tyrosine phosphatase receptor type mu polypeptide antibody; Protein-tyrosine phosphatase mu antibody; PTPRL1 antibody; Ptprm antibody; PTPRM protein antibody; PTPRM_HUMAN antibody; R PTP mu antibody; R-PTP-mu antibody; Receptor type tyrosine protein phosphatase mu antibody; Receptor-type tyrosine-protein phosphatase mu antibody; RPTP mu antibody; RPTPM antibody; RPTPU antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human PTPRM

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:10000
IHC	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Gene References into Functions

Study determined that, in addition to the furin-processed form of PTPmicro, a pool of 200 kDa full-length PTPmicro exists at the plasma membrane that is cleaved directly by ADAM to generate a larger shed form of the PTPmicro extracellular segment. PMID: 24771611
Decreased expression of PTPRM in breast cancer is correlated with poor prognosis and inversely correlated with disease-free survival. PMID: 23185569
Loss of PTPmu by proteolysis causes glioblastoma. PMID: 22505657
Results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPmu protein expression. PMID: 21743492
In A549 cells, diverse injurious stimuli dramatically reduced PTPmu protein expression. PMID: 21649524
Loss of protein tyrosine phosphatase receptor type mu is associated with glioma cell migration and progression. PMID: 19304959
RPTPmu may play a role in the regulation of cardiovascular functions PMID: 12895029
PTPmu may regulate Rho-GTPase-dependent functions of IQGAP1 PMID: 16380380
a 3.1 angstrom crystal structure of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended and rigid architecture, matching the dimensions of adherens junctions is described PMID: 17761881
BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway. PMID: 18773424
loss of cell surface PTPmu by proteolysis generates catalytically active PTPmu fragments that contribute to migration and survival of glioblastoma cells PMID: 19690139

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein-tyrosine phosphatase family, Receptor class 2B subfamily

Database Links

HGNC: 9675

OMIM: 176888

KEGG: hsa:5797

STRING: 9606.ENSP00000331418

UniGene: Hs.49774

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Adherens junction

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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