PTPRM Antibody

1. Study determined that, in addition to the furin-processed form of PTPmicro, a pool of 200 kDa full-length PTPmicro exists at the plasma membrane that is cleaved directly by ADAM to generate a larger shed form of the PTPmicro extracellular segment. PMID: 24771611
2. Decreased expression of PTPRM in breast cancer is correlated with poor prognosis and inversely correlated with disease-free survival. PMID: 23185569
3. Loss of PTPmu by proteolysis causes glioblastoma. PMID: 22505657
4. Results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPmu protein expression. PMID: 21743492
5. In A549 cells, diverse injurious stimuli dramatically reduced PTPmu protein expression. PMID: 21649524
6. Loss of protein tyrosine phosphatase receptor type mu is associated with glioma cell migration and progression. PMID: 19304959
7. RPTPmu may play a role in the regulation of cardiovascular functions PMID: 12895029
8. PTPmu may regulate Rho-GTPase-dependent functions of IQGAP1 PMID: 16380380
9. a 3.1 angstrom crystal structure of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended and rigid architecture, matching the dimensions of adherens junctions is described PMID: 17761881
10. BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway. PMID: 18773424
11. loss of cell surface PTPmu by proteolysis generates catalytically active PTPmu fragments that contribute to migration and survival of glioblastoma cells PMID: 19690139

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HGNC: 9675

OMIM: 176888

KEGG: hsa:5797

STRING: 9606.ENSP00000331418

UniGene: Hs.49774