PTPRR Antibody

Datasheet

Code	CSB-PA624019LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA624019LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA624019LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PTPRR Polyclonal antibody

Uniprot No.

Q15256

Target Names

PTPRR

Alternative Names

Ch-1PTPase antibody; Ch1 PTPase antibody; DKFZp781C1038 antibody; EC PTP antibody; ECPTP antibody; FLJ34328 antibody; MGC131968 antibody; MGC148170 antibody; NC PTPCOM1 antibody; NC-PTPCOM1 antibody; Protein tyrosine phosphatase Cr1PTPase precursor antibody; Protein tyrosine phosphatase NC PTPCOM1 antibody; Protein tyrosine phosphatase PCPTP1 antibody; Protein tyrosine phosphatase receptor type R antibody; Protein-tyrosine phosphatase PCPTP1 antibody; PTP SL antibody; PTPBR7 antibody; PTPRQ antibody; PTPRR antibody; PTPRR_HUMAN antibody; PTPSL antibody; R-PTP-R antibody; Receptor type tyrosine protein phosphatase R antibody; Receptor-type tyrosine-protein phosphatase R antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Receptor-type tyrosine-protein phosphatase R protein (1-412AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PTPRR Antibody (Product code: CSB-PA624019LA01HU) is Non-conjugated. For PTPRR Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA624019LB01HU	PTPRR Antibody, HRP conjugated	ELISA
FITC	CSB-PA624019LC01HU	PTPRR Antibody, FITC conjugated
Biotin	CSB-PA624019LD01HU	PTPRR Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus.

Gene References into Functions

The PTPRR genes were related to possible endophenotypes for suicidal behaviour such as anger, depression-anxiety and fatigue. PMID: 28327445
The development of MDD may be related with the polymorphism of ERK-rs12678428 and PTPRR-rs1513105. PMID: 28467119
Results show that PTPRR is an early and direct target of the androgen receptor which negatively regulates the RAS/ERK1/2 pathway suggesting that its loss in prostate cancer cells is one factor that might contribute to activation of the RAS/ERK1/2 pathway. PMID: 25592066
High expression of PTP receptors R and Z1 was observed in all examined cases of colorectal carcinoma, adenoma and normal colon tissue in this study. PMID: 24242166
The methylation index of PTPRR recovered from scrapings of uterine cervix adenocarcinomas is significantly higher than in normal controls. PMID: 24407576
3 genes identified by association study and supported by ocular expression and/or replication, UHRF1BP1L, PTPRR, and PPFIA2, are novel candidates for myopic development within the MYP3 locus that should be further studied. PMID: 23422819
Methylation of the PTPRR promoter has an important role in the metastasis and may be a biomarker of invasive cervical cancer PMID: 22330137
the protein tyrosine phosphatase receptor type R gene may play a role in conferring risk of major depressive disorder in females PMID: 22100128
expression of the PTPRR-1 isoform was inactivated in colorectal cancer cells as a result of de novo CpG island methylation and enrichment of transcription-repressive histone-tail marks, mainly H3K27me3 PMID: 20015382

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Subcellular Location

[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.; [Isoform Gamma]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.

Protein Families

Protein-tyrosine phosphatase family, Receptor class 7 subfamily

Tissue Specificity

Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta,

Database Links

HGNC: 9680

OMIM: 602853

KEGG: hsa:5801

STRING: 9606.ENSP00000283228

UniGene: Hs.506076

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

MAPK signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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