Phospho-HCLS1 (Y378) Antibody

1. these studies indicate HS1 plays an important role in ROR1-dependent Wnt5a-enhanced chemokine-directed leukemia-cell migration. PMID: 28465529
2. SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells. PMID: 25359136
3. Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. PMID: 23017497
4. interaction of HCLS1 with LEF-1 is essential for G-CSF-triggered myeloid differentiation; data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo PMID: 23001182
5. HS1 overexpressed in leukemic as compared to normal B lymphocytes. PMID: 22768161
6. a novel role for HS1 and its phosphorylation during neutrophil directed migration. PMID: 22679023
7. High HS1 expression predicts poor survival of chronic lymphocytic leukemia patients. PMID: 22333038
8. SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs. PMID: 21287358
9. HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in chronic lymphocytic leukemia. PMID: 20530793
10. substrate for caspase cleavage during apoptosis PMID: 11689006
11. TBB induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. PMID: 11988074
12. found in cell types other than hematopoietic cells PMID: 15754022
13. HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets PMID: 15795233
14. The HS1 coiled-coil region acts synergistically with the repeat domain in the modulation of the Arp2/3 complex-mediated actin polymerization. PMID: 16157603
15. HS1 may play a role in cytoskeleon organization in B-cells and leukemic B-cells PMID: 17508001

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HGNC: 4844

OMIM: 601306

KEGG: hsa:3059

STRING: 9606.ENSP00000320176

UniGene: Hs.14601