RAB39B Antibody

Code CSB-PA822194LA01HU
Size US$166
Order now
Image
  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA822194LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA822194LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA822194LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RAB39B Polyclonal antibody
Uniprot No.
Target Names
RAB39B
Alternative Names
RAB39B antibody; Ras-related protein Rab-39B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ras-related protein Rab-39B protein (1-213AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RAB39B Antibody (Product code: CSB-PA822194LA01HU) is Non-conjugated. For RAB39B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA822194LB01HU RAB39B Antibody, HRP conjugated ELISA
FITC CSB-PA822194LC01HU RAB39B Antibody, FITC conjugated
Biotin CSB-PA822194LD01HU RAB39B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission.
Gene References into Functions
  1. we report on two novel RAB39B frameshift variants associated with X-linked Parkinsonism associated with Intellectual Disability and we also describe, for the first time, a somatic mosaicism in a patient carrying RAB39B mutation PMID: 28851564
  2. results suggest that RAB39B mutation is very rare in familial PD and may not be a major cause of familial PD in the Chinese Han Population PMID: 27694831
  3. This study identified two patients carrying a variant in RAB39B out of 344 male patients with Parkinsonsim. PMID: 27448726
  4. Direct sequencing analysis of all coding exons and exon-intron boundaries was performed to detect small sequence alterations in RAB39B gene PMID: 27036214
  5. penetrance for autism spectrum disorder is high among males but more variable among females with RAB39B mutations; a critical role for this gene in brain development and function is demonstrated PMID: 29152164
  6. X-linked juvenile parkinsonism could be caused by a RAB39B mutation, and basal ganglia calcification may be a novel clinical feature of RAB39B-related parkinsonism. PMID: 27943471
  7. RAB39B mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies in Caucasian population PMID: 27459931
  8. RAB39B mutations are not a common cause of early-onset or familial PD in our Taiwanese population. PMID: 27838047
  9. RAB39B mutations are a rare finding in Parkinson disease patients PMID: 26739247
  10. RAB39B is an essential regulator of vesicular-trafficking in clinically typical Parkinson's disease PMID: 26399558
  11. It plays little or no role in the development of PD in Chinese population. PMID: 26163985
  12. RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition PMID: 25784538
  13. The loss of RAB39B results in dysregulation of alpha-synuclein homeostasis and a spectrum of neuropathological features that implicate RAB39B in the pathogenesis of Parkinson disease and potentially other neurodegenerative disorders. PMID: 25434005
  14. increased dosage of RAB39B causes a disturbed neuronal development leading to cognitive impairment PMID: 24357492
  15. Data indicate that myosin Va interacted with multiple new Rab subfamilies including Rab6, Rab14 and Rab39B. PMID: 24006491
  16. These results demonstrate developmental and functional neuronal alteration as a consequence of downregulation of RAB39B and emphasize the critical role of vesicular trafficking in the development of neurons and human intellectual abilities. PMID: 20159109
  17. RAB39B was expressed in a variety of human tissues and located in human chromosome Xq28. PMID: 12438742

Show More

Hide All

Involvement in disease
Mental retardation, X-linked 72 (MRX72); Waisman syndrome (WSMN)
Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus.
Protein Families
Small GTPase superfamily, Rab family
Tissue Specificity
Highly expressed in the brain.
Database Links

HGNC: 16499

OMIM: 300271

KEGG: hsa:116442

STRING: 9606.ENSP00000358466

UniGene: Hs.632832

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*