Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
Gene References into Functions
- vesicle-associated RhoB is a regulator of the Rab11-mediated recycling of LFA-1 to the cell surface, an event that is necessary for T lymphocyte motility. PMID: 29233918
- Rab43 directly interacts with GPCRs and controls the forward ER-to-Golgi traffic of nascent GPCRs. PMID: 29069590
- High RAB43 expression is associated with epithelial-mesenchymal transition in gliomas. PMID: 28075478
- several crystal structures of the myosin Va or the myosin Vb globular tail domain that gives insights into how the motor is linked to the recycling membrane compartments via Rab11 or the melanophilin adaptor that binds to Rab27a. PMID: 24248336
- Data indicate taht the parasitophorous vacuole (PV), marked with Rab14, Rab30, or Rab43, colocalize with host-derived sphingolipids in the vacuolar space. PMID: 23615442
- SGK1,3 enhances the expression level of mature hERG channels by inhibiting Nedd4-2 as well as by promoting Rab11-mediated hERG recycling. PMID: 23589291
- Rab1a/b and Rab43, are important for herpes simplex virus 1 virion assembly PMID: 21680502
- The results of PCR amplification indicated that human RAB41 is widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver. PMID: 15018353
- Rab43 is the target of RN-tre and is required for Shiga toxin uptake. PMID: 17562788
- Results indicate that Rab1 and Rab43 are key Rabs required for the biogenesis and maintenance of a functional Golgi structure, and suggest that other Rabs acting at the Golgi complex are likely to be functionally redundant. PMID: 17684057
- Rab18 and Rab43 have key roles in ER-Golgi trafficking. PMID: 18664496
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Subcellular Location
Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network.
Protein Families
Small GTPase superfamily, Rab family
Tissue Specificity
Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.
