RAB6A Antibody

1. Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. PMID: 27550519
2. Rab6A binding to KIF1C's motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C's cellular functions. PMID: 25821985
3. GORAB missense mutation disrupt RAB6 protein binding in genetic skin diseases. PMID: 26000619
4. several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells PMID: 25962623
5. Data suggest that miR-5100 promotes tumor growth by facilitating the G1/S transition and targeting Rab6. PMID: 25754817
6. Data indicate that myosin Va interacted with multiple new Rab subfamilies including Rab6, Rab14 and Rab39B. PMID: 24006491
7. Mint1 826 bridges APP to the small GTPase PMID: 23737971
8. The presence of an active pool of Rab6 within host cells early during infection is required to support efficient intracellular growth of L. pneumophila. PMID: 23569112
9. Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. PMID: 23091056
10. GTP-bound form of Rab6 promotes retrograde trafficking of cav-2 from the Golgi to ER PMID: 22607032
11. the crystal structure of the human Rab6A'(Q72L) mutant form at 1.9A resolution is reported. PMID: 22750005
12. Rab6 modulates the unfolded protein response (UPR), increased levels inhibit whereas decreased levels augment UPR induction. PMID: 22124028
13. Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number PMID: 22335553
14. Rab6 is required for Rab8A association with exocytotic vesicles. PMID: 21596566
15. In contrast to wild-type R6IP1-Rab6 crystals, which took several weeks to grow to full size, the engineered R6IP1 (RPdel)-Rab6 crystals could be grown in a matter of days PMID: 21543860
16. The authors found that the small GTPase Rab6 also interacts indirectly with cytomegalovirus pp150 through its interaction with Bicaudal D1. PMID: 21411515
17. Data show that Rab6, a Golgi-associated Rab, forms a complex with myosin II, contributes to its localization at the Golgi complex and, unexpectedly, controls the fission of Rab6 vesicles. PMID: 20562865
18. recombinant antibodies specific to the GTP-bound conformation of Rab6 were generated and used to locate Rab6; Rab6 was in its GTP-bound conformation on the Golgi apparatus and transport intermediates PMID: 12738866
19. Rab6A and Rab6A' regulate microtubule-dependent recycling at the trans-Golgi network PMID: 15483056
20. 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h. GTP binding activity, RaB small monomeric GTPase activity, protein transporter activity. PMID: 15747776
21. Results show the crystal structure of the GTPase Rab6A in the GTP bound form. PMID: 16332443
22. Rab6A' likely regulates the dynamics of the dynein/dynactin complex at the kinetochores and consequently the inactivation of the Mad2-spindle checkpoint. PMID: 16395330
23. Results show that Rab6A and Rab6A' perform different functions within the cell and suggests a novel role for Rab6A' as the major Rab6 isoform regulating previously described Rab6-dependent transport pathways. PMID: 16536738
24. role of the Rab6 isoforms in retrograde transport of ricin using both oligo- and vector-based RNAi assays PMID: 16683916
25. a highly significant correlation between the Rab6 and the UPR marker BiP in Alzheimer disease brains. PMID: 17573808
26. These data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space. PMID: 17681140
27. Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG. PMID: 17699596
28. DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi. PMID: 18044744
29. Data show that iPLA(1)gamma is a novel membrane transport factor that contributes to a specific Golgi-to-ER retrograde pathway distinct from presently characterized COPI- and Rab6-dependent pathways. PMID: 19632984
30. Study demonstrates that Golgi recruitment of endogenous GCC185 does not involve Rab6A/A' and Arl1. PMID: 19703403

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HGNC: 9786

OMIM: 179513

KEGG: hsa:5870

STRING: 9606.ENSP00000311449

UniGene: Hs.503222