RAP2A Antibody

1. The small GTPase Ras-related protein 2 (Rap2) was found to bind ArrB1 under resting conditions but dissociated upon formyl-Met-Leu-Phe stimulation. PMID: 27493245
2. Nedd4-1 inhibited Rap2a activity, and promoted the migration and invasion of glioma cells. PMID: 28405688
3. present review mainly focused on recent studies on the functional and physical interactions between Rap2 and its effectors. We also speculated on the relevance of these pathways to tumorigenesis PMID: 25980814
4. Single nucleotide polymorphism in RAP2A gene is associated with Peripheral Arterial Disease. PMID: 26488411
5. the role of Rap2a in carcinogenesis PMID: 25248704
6. The ectopic expression of Rap2a enhances the migration and invasive ability of cancer cells and increases activities of matrix metalloproteinase MMP2 and MMP9. PMID: 25728512
7. downregulation of Rap2a promoted glioma migration and invasion, and raised the phosphorylation level of AKT PMID: 24293123
8. Rap2A and TNIK control brush border formation by apical recruitment of MST4 and the subsequent phosphorylation of Ezrin PMID: 22797597
9. Rap2 enhanced MAP4K4-induced activation of JNK PMID: 14966141
10. TNIK is a specific effector of Rap2 to regulate actin cytoskeleton PMID: 15342639
11. RGS14 activity towards heterotrimeric G-proteins, as either a GAP or a guanine nucleotide dissociation inhibitor, was unaffected by Rap binding. PMID: 16246175
12. Rap2 is involved in androgen-mediated transcriptional and growth responses of human prostate cancer cells. PMID: 17918750
13. Study presents evidence of fewer spines and reduced signaling in Rap2 transgenic mice, consistent with an inhibitory role for Rap2 at synapses. PMID: 18701680
14. analyzed residues that allow RasGEF1 proteins to discriminate between Rap1 and Rap2, and identified Phe39 in the switch I region of Rap2 as a specificity residue. PMID: 19645719

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HGNC: 9861

OMIM: 179540

KEGG: hsa:5911

STRING: 9606.ENSP00000245304

UniGene: Hs.508480