RGS3 Antibody

Code CSB-PA019655ESR1HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RGS3 Polyclonal antibody
Uniprot No.
Target Names
RGS3
Alternative Names
C2PA antibody; FLJ20370 antibody; FLJ31516 antibody; FLJ90496 antibody; PDZ RGS 3 antibody; PDZ RGS3 antibody; Regulator of G protein signaling 3 antibody; Regulator of G protein signalling 3 antibody; Regulator of G-protein signaling 3 antibody; RGP 3 antibody; RGP3 antibody; RGS 3 antibody; RGS3 antibody; RGS3_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Regulator of G-protein signaling 3 protein (1-270AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
Gene References into Functions
  1. It has been reported that mitotic kinesin KIF20A interacts with RGS3 and plays a crucial role in controlling the division modes of neural progenitor cells during cortical neurogenesis. PMID: 30006548
  2. Findings suggest that overexpressed RGS3 regulated by microRNA-126 through the post-transcriptional modulation is associated significantly with a poor prognosis of GC patients. PMID: 27754994
  3. Our data provide a novel miR-25/RGS3 signal in the development of lung cancer. PMID: 26416661
  4. cardiac overexpression of RGS3 inhibits maladaptive hypertrophy and fibrosis and improves cardiac function by blocking MEK-ERK1/2 signaling PMID: 24375609
  5. PDZ-RGS3 can enhance signals generated by the Wnt canonical pathway and plays a pivotal role in epithelial mesenchymal transition PMID: 22859293
  6. Results suggest that the 14-3-3 protein binding affects the structure of the Galpha interaction portion of RGS3 as well as sterically blocks the interaction between the RGS domain and the Galpha subunit of heterotrimeric G proteins. PMID: 22027839
  7. 14-3-3 protein binding induces structural changes in both the N-terminal part and the C-terminal RGS domain of phosphorylated RGS3 molecule PMID: 20347994
  8. Regulator of G-protein signalling 3 (RGS3) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure. PMID: 19778949
  9. Data are consistent with the model wherein 14-3-3 serves as a scavenger of RGS3, regulating the amounts of RGS3 available for binding G-proteins. PMID: 11985497
  10. C2PA is expressed in the cell nucleus and induces heat shock response element (HSE)-dependent gene transcription PMID: 12210723
  11. RFS3 promoted the conversion of more stable Ca2+ elevations into oscillatory signals. PMID: 15383626
  12. mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel. PMID: 16821082
  13. Full-length RGS3, RGS3T, and the core domain of RGS3 were equally effective in antagonizing inhibition of Ca(V)2.3 through M(2)R. PMID: 16855219
  14. This study identifies a novel, noncanonical role of RGS3 in regulation of TGF-beta signaling through its interaction with Smads and interfering with Smad heteromerization. PMID: 18287247
  15. in apoptosis-initiated cells, the ligand-dependent C5aR-mediated dual signal affects the fate of cells, either apoptosis execution or survival, through regulation of RGS3 gene expression and subsequent modulation of ERK signal. PMID: 19333232

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Subcellular Location
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).
Database Links

HGNC: 9999

OMIM: 602189

KEGG: hsa:5998

STRING: 9606.ENSP00000259406

UniGene: Hs.494875

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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