RLIM Antibody

Code CSB-PA019748GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RLIM
Alternative Names
E3 ubiquitin-protein ligase RLIM antibody; LIM domain-interacting RING finger protein antibody; R-LIM antibody; Renal carcinoma antigen NY-REN-43 antibody; RING finger LIM domain-binding protein antibody; RING finger protein 12 antibody; RLIM antibody; RNF12 antibody; RNF12_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human RLIM
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Gene References into Functions
  1. Results from a study on gene expression variability markers in early-stage human embryos shows that RLIM is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
  2. missense mutation in RLIM gene was identified in four males with intellectual disability from a three-generation family. PMID: 25735484
  3. RNF12 is a novel positive regulator of p53 pathway and an external E3 ubiquitin ligase for MDM2 destruction. PMID: 26926424
  4. Rlim is a novel regulator of Stathmin protein in a ubiquitin-dependent manner, and represents a new pathway for malignant phenotype turnover by modulating the level of Stathmin protein in human osteosarcomas. PMID: 24686088
  5. hus regulated nucleocytoplasmic shuttling of RLIM/Rnf12 coordinates cellular compartments during mammary alveolar cell survival PMID: 23904271
  6. TP53 does not directly bind to the RLIM promoter, it physically interacts with and prevents the binding of Sp1 to the RLIM promoter. PMID: 23650532
  7. these results indicated that RLIM is an important positive regulator in TGF-beta signaling pathway and cell migration. PMID: 21945933
  8. RLIM represents a new pathway for telomere maintenance by modulating the level of TRF1 at telomeres. PMID: 19164295
  9. These findings provide evidence for a dose-dependent role of RNF12 in the XCI counting and initiation process. PMID: 19945382
  10. Functional analysis of the Xenopus homolog PMID: 12874135

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Involvement in disease
Mental retardation, X-linked 61 (MRX61)
Subcellular Location
Nucleus.
Protein Families
RNF12 family
Tissue Specificity
Expressed in many tissues.
Database Links

HGNC: 13429

OMIM: 300379

KEGG: hsa:51132

STRING: 9606.ENSP00000253571

UniGene: Hs.653288

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