RNF14 Antibody

Code CSB-PA080036
Size US$100
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Product Details

Uniprot No.
Target Names
RNF14
Alternative Names
Androgen receptor associated protein 54 antibody; Androgen receptor-associated protein 54 antibody; ARA 54 antibody; ARA54 antibody; E3 ubiquitin protein ligase RNF14 antibody; E3 ubiquitin-protein ligase RNF14 antibody; FLJ26004 antibody; HFB 30 antibody; HFB30 antibody; HRIHFB2038 antibody; RING finger protein 14 antibody; RNF 14 antibody; Rnf14 antibody; RNF14_HUMAN antibody; TRIAD 2 antibody; TRIAD2 antibody; Triad2 protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human ARA54.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.
Gene References into Functions
  1. Ring Finger Protein 14 (RNF14) is a binding partner for all TCF/LEF transcription factors. PMID: 23449499
  2. dominant-negative AR coregulator can suppress AR transactivation and cell proliferation in prostate cancer cells PMID: 11673464
  3. ARA54 role in prostate carcinoma progression may in may involve function as androgen receptor coactivator and focal adhesion protein PMID: 12772188
  4. ARA54, might have dual in vivo roles functioning as both a direct coactivator and as an indirect mediator in AR function. PMID: 17082327
  5. Dual functional roles for ARA54 as an AR coregulator directly and as a mediator for the suppressive effect of hnRNP A1 indirectly. PMID: 17110431
  6. mRNA expression of ARA54 correlates with that of cyclin D1 in human colon carcinoma cells, indicating that ARA54 is not only involved in the regulation of cyclin D1 expression in cultured cell lines but also in clinical cancer specimens. PMID: 17510080
  7. Differential localization of ARA54 may play an important role in testicular development and spermatogenesis in humans. PMID: 17919607

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
RBR family, RNF14 subfamily
Tissue Specificity
Widely expressed.
Database Links

HGNC: 10058

OMIM: 605675

KEGG: hsa:9604

STRING: 9606.ENSP00000324956

UniGene: Hs.483616

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