RNGTT Antibody

Datasheet

Code	CSB-PA526449ESR2HU
Size	US$166
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Image	Western blot All lanes: RNGTT antibody at 1.42µg/ml + THP-1 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 69, 67, 53, 62 kDa Observed band size: 69 kDa Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA526449ESR2HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RNGTT Polyclonal antibody

Uniprot No.

O60942

Target Names

RNGTT

Alternative Names

CAP1A antibody; GTase antibody; GTP--RNA guanylyltransferase antibody; hCAP antibody; HCAP1 antibody; HcE antibody; HCE1 antibody; MCE1 antibody; MCE1_HUMAN antibody; mRNA 5''-triphosphatase antibody; mRNA capping enzyme antibody; mRNA guanyltransferase antibody; mRNA guanylyltransferase antibody; Polynucleotide 5' trisphosphatase antibody; RNA guanylyltransferase and 5' phosphatase antibody; RNGTT antibody; TPase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human mRNA-capping enzyme protein (1-260AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.

Gene References into Functions

c-Myc deregulation induces mRNA capping enzyme dependency in tumor cells. PMID: 27756891
These results identify a new domain of CE that is specific to its function in cytoplasmic capping, and a new role for Nck1 in regulating gene expression through its role as the scaffold for assembly of the cytoplasmic capping complex. PMID: 25137142
Our biochemical studies provide the first insight that MZP can inhibit the formation of the RNA cap structure catalyzed by HCE. PMID: 23349942
Data show that human capping enzyme residues 229-567 comprise the minimum enzymatically active human GTase (hGTase) domain and determine the structure by X-ray crystallography. PMID: 21636784

Subcellular Location

Nucleus.

Protein Families

Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family

Tissue Specificity

Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.

Database Links

HGNC: 10073

OMIM: 603512

KEGG: hsa:8732

STRING: 9606.ENSP00000358497

UniGene: Hs.567378

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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