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RPAIN Antibody

Datasheet
Code CSB-PA020093GA01HU
Size $600
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Product Details

Uniprot No.
Q86UA6
Target Names
RPAIN
Alternative Names
2400006N03Rik antibody; DN-393H17.1 antibody; FLJ25625 antibody; FLJ30490 antibody; FLJ42429 antibody; HRIP antibody; MGC4189 antibody; Nuclear transporter antibody; RAP interaction protein antibody; RIP antibody; RIP_HUMAN antibody; RP23 83I13.5 antibody; RPA interacting protein antibody; RPA-interacting protein antibody; Rpain antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human RPAIN
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
Gene References into Functions
  1. Suggest that increased RPAIN levels may contribute to the development of preeclampsia through regulating trophoblast invasion and apoptosis via C1q. PMID: 28032589
  2. hRIPalpha is involved in cell proliferation through regulation of RPA transport PMID: 23010595
  3. The results show that DDX3, eIF5A, and hRIP enhance HIV-1 internal ribosomal entry site-mediated translation. PMID: 21360055
  4. hRIPbeta localises to the PML nuclear body and transports replication protein A (PML) into the PML nuclear body and releases RPA upon UV irradiation. PMID: 16135809
Subcellular Location
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Nucleus, PML body.
Tissue Specificity
Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.
Database Links

HGNC: 28641

OMIM: 617299

KEGG: hsa:84268

STRING: 9606.ENSP00000385814

UniGene: Hs.462086

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