RPL26 Antibody

Code CSB-PA020207LA01HU
Size US$166
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Image
  • Immunofluorescent analysis of HepG2 cells using CSB-PA020207LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • IHC image of CSB-PA020207LA01HU diluted at 1:600 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RPL26 Polyclonal antibody
Uniprot No.
Target Names
RPL26
Alternative Names
tibody; 60S ribosomal protein L26 antibody; 60S ribosomal protein L26 like 1 antibody; DBA11 antibody; FLJ46904 antibody; L26 antibody; OTTHUMP00000135333 antibody; PTB associated splicing factor antibody; Ribosomal protein L26 antibody; Ribosomal protein L26 homolog antibody; Ribosomal protein L26 like 1 antibody; Ribosomal protein L26 pseudogene 1 antibody; RL26_HUMAN antibody; rpl26 antibody; RPL26P1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 60S ribosomal protein L26 protein (48-143AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RPL26 Antibody (Product code: CSB-PA020207LA01HU) is Non-conjugated. For RPL26 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA020207LB01HU RPL26 Antibody, HRP conjugated ELISA
FITC CSB-PA020207LC01HU RPL26 Antibody, FITC conjugated
Biotin CSB-PA020207LD01HU RPL26 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:500-1:1000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Component of the large ribosomal subunit.
Gene References into Functions
  1. ionizing radiation (IR) inhibits the activity of SMG1, a phosphoinositide-3-kinase-like kinase family member, reducing the binding of SMG1 to a specific region near exon 9 of p53 precursor mRNA and promoting the binding of ribosomal protein L26 (RPL26) to p53 pre-mRNA PMID: 28288992
  2. In colorectal tumor cells RPL26 regulates p73 expression via two distinct mechanisms: protein stability and mRNA translation. PMID: 27825141
  3. Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26. PMID: 26687066
  4. The results showed that knockdown of RPL26 or RPL29 expression significantly suppressed cell proliferation, induced cell arrest at G0/G1 phase and enhanced cell apoptosis PMID: 22868929
  5. Northern Blot Together with RPL5, RPL11, and RPS7, RPL26 is the fourth RP regulating p53 activity that is linked to diamond-blackfan anemia. PMID: 22431104
  6. suggest a model in which the base pairings in the p53 UTR interaction regions are critical for both translational repression and stress induction of p53 by NCL and RPL26 PMID: 22433872
  7. Mdm2 binds L26 and drives its polyubiquitylation and proteasomal degradation. PMID: 18951086

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Involvement in disease
Diamond-Blackfan anemia 11 (DBA11)
Protein Families
Universal ribosomal protein uL24 family
Database Links

HGNC: 10327

OMIM: 603704

KEGG: hsa:6154

STRING: 9606.ENSP00000293842

UniGene: Hs.482144

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