Recombinant Human 60S ribosomal protein L26 (RPL26)

Code CSB-YP020207HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP020207HU
MSDS
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Source E.coli
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Code CSB-EP020207HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP020207HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP020207HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
RPL26
Uniprot No.
Alternative Names
PL26L1; 60S ribosomal protein L26; 60S ribosomal protein L26 like 1; DBA11; FLJ46904; L26; OTTHUMP00000135333; PTB associated splicing factor; Ribosomal protein L26 ; Ribosomal protein L26 homolog; Ribosomal protein L26 like 1; Ribosomal protein L26 pseudogene 1; RL26_HUMAN; rpl26; RPL26P1
Species
Homo sapiens (Human)
Expression Region
1-145
Target Protein Sequence
MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEETI EKMQE
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Component of the large ribosomal subunit.
Gene References into Functions
  1. ionizing radiation (IR) inhibits the activity of SMG1, a phosphoinositide-3-kinase-like kinase family member, reducing the binding of SMG1 to a specific region near exon 9 of p53 precursor mRNA and promoting the binding of ribosomal protein L26 (RPL26) to p53 pre-mRNA PMID: 28288992
  2. In colorectal tumor cells RPL26 regulates p73 expression via two distinct mechanisms: protein stability and mRNA translation. PMID: 27825141
  3. Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26. PMID: 26687066
  4. The results showed that knockdown of RPL26 or RPL29 expression significantly suppressed cell proliferation, induced cell arrest at G0/G1 phase and enhanced cell apoptosis PMID: 22868929
  5. Northern Blot Together with RPL5, RPL11, and RPS7, RPL26 is the fourth RP regulating p53 activity that is linked to diamond-blackfan anemia. PMID: 22431104
  6. suggest a model in which the base pairings in the p53 UTR interaction regions are critical for both translational repression and stress induction of p53 by NCL and RPL26 PMID: 22433872
  7. Mdm2 binds L26 and drives its polyubiquitylation and proteasomal degradation. PMID: 18951086

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Involvement in disease
Diamond-Blackfan anemia 11 (DBA11)
Protein Families
Universal ribosomal protein uL24 family
Database Links

HGNC: 10327

OMIM: 603704

KEGG: hsa:6154

STRING: 9606.ENSP00000293842

UniGene: Hs.482144

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