SEMA6A Antibody

Datasheet

Code	CSB-PA875655YA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA875655YA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA875655YA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SEMA6A Polyclonal antibody

Uniprot No.

Q9H2E6

Target Names

SEMA6A

Alternative Names

HT018 antibody; SEM6A_HUMAN antibody; SEMA antibody; Sema domain; transmembrane domain (TM); and cytoplasmic domain; (semaphorin) 6A antibody; Sema Q antibody; Sema VIA antibody; SEMA6A 1 antibody; Sema6a antibody; SEMA6A-1 antibody; SEMA6A1 antibody; Semaphorin 6A 1 antibody; Semaphorin Q antibody; Semaphorin VIA antibody; Semaphorin-6A antibody; Semaphorin-6A-1 antibody; SEMAQ antibody; VIA antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Semaphorin-6A protein (755-990AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SEMA6A Antibody (Product code: CSB-PA875655YA01HU) is Non-conjugated. For SEMA6A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA875655YB01HU	SEMA6A Antibody, HRP conjugated	ELISA
FITC	CSB-PA875655YC01HU	SEMA6A Antibody, FITC conjugated
Biotin	CSB-PA875655YD01HU	SEMA6A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.; (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.

Gene References into Functions

describes the experiments and methods enabling the characterization of Semaphorin 6A as a critical regulator of endothelial cell survival and vessel function PMID: 27787863
miR-203 induces the apoptosis of YD-38 human oral cancer cells by directly targeting SEMA6A. PMID: 28982852
our findings indicated that SEMA6A may be a potential prognostic biomarker in the treatment of Glioblastoma multiforme PMID: 26014517
Data suggest that Sema6A and Mical1 may represent new potential therapeutic targets in BRAFV600E melanoma. PMID: 25576923
We identified the SEMA6A and HLA-DP loci as significant contributors to risk for granulomatosis with polyangiitis. PMID: 23740775
Data show that miR-27a/b regulated the expression of the angiogenesis inhibitor semaphorin 6A (SEMA6A) in vitro and in vivo and targeted the 3'-untranslated region of SEMA6A. PMID: 22184411
Strong expression of SEMA6A is associated with langerhans cells of histiocytosis or dermatopathic lymphadenitis PMID: 16436660
NANOG-, SOX2-, and POU5F1 (OCT3/OCT4)-binding sites within intron 1 of the SEMA6A gene PMID: 17671748
findings suggest for SEMA6A a novel function in the cytoskeleton and a role in modulating tubulin isotype composition and microtubule dynamics PMID: 18187809

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Semaphorin family

Database Links

HGNC: 10738

OMIM: 605885

KEGG: hsa:57556

STRING: 9606.ENSP00000345512

UniGene: Hs.156967

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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