SEMA6A Antibody, Biotin conjugated

Code CSB-PA875655YD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SEMA6A Polyclonal antibody
Uniprot No.
Target Names
SEMA6A
Alternative Names
HT018 antibody; SEM6A_HUMAN antibody; SEMA antibody; Sema domain; transmembrane domain (TM); and cytoplasmic domain; (semaphorin) 6A antibody; Sema Q antibody; Sema VIA antibody; SEMA6A 1 antibody; Sema6a antibody; SEMA6A-1 antibody; SEMA6A1 antibody; Semaphorin 6A 1 antibody; Semaphorin Q antibody; Semaphorin VIA antibody; Semaphorin-6A antibody; Semaphorin-6A-1 antibody; SEMAQ antibody; VIA antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Semaphorin-6A protein (755-990AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.; (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.
Gene References into Functions
  1. describes the experiments and methods enabling the characterization of Semaphorin 6A as a critical regulator of endothelial cell survival and vessel function PMID: 27787863
  2. miR-203 induces the apoptosis of YD-38 human oral cancer cells by directly targeting SEMA6A. PMID: 28982852
  3. our findings indicated that SEMA6A may be a potential prognostic biomarker in the treatment of Glioblastoma multiforme PMID: 26014517
  4. Data suggest that Sema6A and Mical1 may represent new potential therapeutic targets in BRAFV600E melanoma. PMID: 25576923
  5. We identified the SEMA6A and HLA-DP loci as significant contributors to risk for granulomatosis with polyangiitis. PMID: 23740775
  6. Data show that miR-27a/b regulated the expression of the angiogenesis inhibitor semaphorin 6A (SEMA6A) in vitro and in vivo and targeted the 3'-untranslated region of SEMA6A. PMID: 22184411
  7. Strong expression of SEMA6A is associated with langerhans cells of histiocytosis or dermatopathic lymphadenitis PMID: 16436660
  8. NANOG-, SOX2-, and POU5F1 (OCT3/OCT4)-binding sites within intron 1 of the SEMA6A gene PMID: 17671748
  9. findings suggest for SEMA6A a novel function in the cytoskeleton and a role in modulating tubulin isotype composition and microtubule dynamics PMID: 18187809

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Semaphorin family
Database Links

HGNC: 10738

OMIM: 605885

KEGG: hsa:57556

STRING: 9606.ENSP00000345512

UniGene: Hs.156967

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