SHCBP1 Antibody

Datasheet

Code	CSB-PA847699LA01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SHCBP1 Polyclonal antibody

Uniprot No.

Q8NEM2

Target Names

SHCBP1

Alternative Names

FLJ22009 antibody; PAL antibody; Protein expressed in Activated Lymphocytes antibody; SHC binding and spindle associated 1 antibody; SHC SH2 domain-binding protein 1 antibody; SHCBP_HUMAN antibody; Shcbp1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human SHC SH2 domain-binding protein 1 protein (211-500AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SHCBP1 Antibody (Product code: CSB-PA847699LA01HU) is Non-conjugated. For SHCBP1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA847699LB01HU	SHCBP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA847699LC01HU	SHCBP1 Antibody, FITC conjugated
Biotin	CSB-PA847699LD01HU	SHCBP1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.

Gene References into Functions

SHCBP1 was found highly expressed in SS cell lines and tissues, which was linked to the poor clinical prognosis and was implicated in SS aggressive progression. SHCBP1 regulated invasion and metastasis by modulating the TGF-beta1/Smad signaling pathway and promoting the EMT in SS. PMID: 29020987
Data indicate that the oncogene SS18-SSX1 promotes tumorigenesis by increasing the expression of SHC SH2-domain binding protein 1 (SHCBP1), which normally acts as a tumor promoting factor. PMID: 27572315
Immunohistochemical analysis revealed SHCBP1 was significantly up-regulated in breast cancer tissues compared with adjacent normal tissues (82 of 128, 64%). Over-expressed SHCBP1 was correlated with advanced clinical stage and poorer survival. Ablation of SHCBP1 inhibited the proliferation in vitro. PMID: 27129942
This study gives novel insight into the role of SHCBP in cytokinesis completion. PMID: 25486361
Knockdown of SHCBP1 induced cell cycle delay. PMID: 24289556
The central region of SHCBP1 was found to bind to measles virus C protein, as well as the phosphoprotein, but the two viral proteins did not compete for SHCBP1 binding. PMID: 23804634

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Subcellular Location

Midbody. Cytoplasm, cytoskeleton, spindle.

Database Links

HGNC: 29547

OMIM: 611027

KEGG: hsa:79801

STRING: 9606.ENSP00000306473

UniGene: Hs.123253

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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