SHMT2 Antibody

1. Findings support the hypothesis that age-associated respiration defects in fibroblasts of elderly humans are caused not by mtDNA mutations but by epigenetic regulation of nuclear genes including SHMT2. PMID: 29323231
2. SHMT2 Desuccinylation is associated with Cancer Cell Proliferation. PMID: 29180469
3. Our data confirm the heterogeneity of breast tumors at a functional proteomic level and dissects the relationship between metabolism-related proteins, pathological features and patient survival. These observations highlight the importance of SHMT2 and ASCT2 as valuable individual prognostic markers and potential targets for personalized breast cancer therapy PMID: 29020998
4. Data suggest that serine hydroxymethyltransferase 2 (SHMT2) may be a potential target in the treatment of hepatocellular carcinoma (HCC). PMID: 27391339
5. High SHMT2 expression is associated with idiopathic pulmonary fibrosis. PMID: 27836973
6. These results indicate that SHMT2 may be a valuable prognostic biomarker in ER-negative breast cancer cases PMID: 27666119
7. our results for the first time showed that miR-615-5p prevents proliferation and migration through negatively regulating SHMT2 in HCC. PMID: 26662310
8. The SHMT-2 is the direct targets of miR-370 and miR-373, respectively, in human articular chondrocytes. PMID: 26103880
9. High SHMT2 expression increases glycine-dependent nucleotide synthesis leading to bladder cancer growth. PMID: 26975021
10. SHMT2 is required for glioblastoma multiforme cells to adapt to the tumour environment, but also renders these cells sensitive to glycine cleavage system inhibition PMID: 25855294
11. This paper compares the mitochondrial and cytoplasmic forms of this enzyme and suggests that the two genes are a result of a single gene duplication. PMID: 9573390

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HGNC: 10852

OMIM: 138450

KEGG: hsa:6472

STRING: 9606.ENSP00000333667

UniGene: Hs.741179