SLC17A1 Antibody

Datasheet

Code	CSB-PA021417GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q14916

Target Names

SLC17A1

Alternative Names

Na(+)/PI cotransporter 1 antibody; Na/Pi-4 antibody; NAP 1 antibody; Napi1 antibody; NPT 1 antibody; Npt1 antibody; NPT1_HUMAN antibody; Renal Na(+)-dependent phosphate cotransporter 1 antibody; Renal sodium-dependent phosphate transport protein 1 antibody; Renal sodium-phosphate transport protein 1 antibody; Slc17a1 antibody; Sodium phosphate transporter antibody; Sodium-dependent phosphate transport protein 1 antibody; Sodium/phosphate cotransporter 1 antibody; Sodium/phosphate type I cotransporter antibody; Solute carrier family 17 (organic anion transporter) member 1 antibody; solute carrier family 17 (sodium phosphate), member 1 antibody; Solute carrier family 17 (vesicular glutamate transporter) member 1 antibody; Solute carrier family 17 member 1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human SLC17A1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney.

Gene References into Functions

A meta-analysis of all gout with Japanese, Caucasian and NZ Polynesian populations revealed that rs2285340 of SLC22A12 and rs1165196 of SLC17A1 showed a significant association but did not reach a genome-wide significance level. PMID: 27899376
I269T, a common missense variant of NPT1, might have faster conformation changes than NPT1 wild type in terms of the alternating-access model of transporters, and increases renal urate export in humans. PMID: 27906618
Data suggest that single nucleotide polymorphisms (SNPs) of solute carrier family 17 member 1 (SLC17A1) are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men. PMID: 26524967
Data suggest that single nucleotide polymorphisms (SNPs) rs9467596 and rs2096386 of the solute carrier family 17 (sodium phosphate), member 1 protein (SLC17A1) gene may have a correlation between hyperuricemia and alcohol drinking among Uygur patients. PMID: 26663070
Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males. PMID: 26290326
NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout. PMID: 25252215
NPT1 is responsible for urate excretion under physiological conditions and its impairment is linked with the occurrence of gout. [review] PMID: 23876149
We observed a clear effect of SLC17A1 genotype on fructose load in Europeans but not Polynesian subgroups. PMID: 23852697
Renal urate transporter SLC17A1 is the third locus associated with gout at a genome-wide level of significance. PMID: 22541845
results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions PMID: 20566650
data suggest that SLC17A1 polymorphisms are associated with the development of gout. PMID: 19556210
structure and promoter activity, molecular cloning PMID: 11704559

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Subcellular Location

Apical cell membrane; Multi-pass membrane protein.

Protein Families

Major facilitator superfamily, Sodium/anion cotransporter family

Tissue Specificity

Expressed in kidney cortex, liver and brain but not in other tissues.

Database Links

HGNC: 10929

OMIM: 182308

KEGG: hsa:6568

STRING: 9606.ENSP00000244527

UniGene: Hs.205816

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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