Recombinant Human Sodium-dependent phosphate transport protein 1 (SLC17A1), partial

Code CSB-YP617940HU
MSDS
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Source Yeast
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Code CSB-EP617940HU
MSDS
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Source E.coli
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Code CSB-EP617940HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP617940HU
MSDS
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Source Baculovirus
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Code CSB-MP617940HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SLC17A1
Uniprot No.
Alternative Names
Na(+)/PI cotransporter 1; Na/Pi-4; NAP 1; Napi1; NPT 1; Npt1; NPT1_HUMAN; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Slc17a1; Sodium phosphate transporter; Sodium-dependent phosphate transport protein 1; Sodium/phosphate cotransporter 1; Sodium/phosphate type I cotransporter; Solute carrier family 17 (organic anion transporter) member 1; solute carrier family 17 (sodium phosphate), member 1; Solute carrier family 17 (vesicular glutamate transporter) member 1; Solute carrier family 17 member 1
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney.
Gene References into Functions
  1. A meta-analysis of all gout with Japanese, Caucasian and NZ Polynesian populations revealed that rs2285340 of SLC22A12 and rs1165196 of SLC17A1 showed a significant association but did not reach a genome-wide significance level. PMID: 27899376
  2. I269T, a common missense variant of NPT1, might have faster conformation changes than NPT1 wild type in terms of the alternating-access model of transporters, and increases renal urate export in humans. PMID: 27906618
  3. Data suggest that single nucleotide polymorphisms (SNPs) of solute carrier family 17 member 1 (SLC17A1) are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men. PMID: 26524967
  4. Data suggest that single nucleotide polymorphisms (SNPs) rs9467596 and rs2096386 of the solute carrier family 17 (sodium phosphate), member 1 protein (SLC17A1) gene may have a correlation between hyperuricemia and alcohol drinking among Uygur patients. PMID: 26663070
  5. Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males. PMID: 26290326
  6. NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout. PMID: 25252215
  7. NPT1 is responsible for urate excretion under physiological conditions and its impairment is linked with the occurrence of gout. [review] PMID: 23876149
  8. We observed a clear effect of SLC17A1 genotype on fructose load in Europeans but not Polynesian subgroups. PMID: 23852697
  9. Renal urate transporter SLC17A1 is the third locus associated with gout at a genome-wide level of significance. PMID: 22541845
  10. results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions PMID: 20566650
  11. data suggest that SLC17A1 polymorphisms are associated with the development of gout. PMID: 19556210
  12. structure and promoter activity, molecular cloning PMID: 11704559

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Subcellular Location
Apical cell membrane; Multi-pass membrane protein.
Protein Families
Major facilitator superfamily, Sodium/anion cotransporter family
Tissue Specificity
Expressed in kidney cortex, liver and brain but not in other tissues.
Database Links

HGNC: 10929

OMIM: 182308

KEGG: hsa:6568

STRING: 9606.ENSP00000244527

UniGene: Hs.205816

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