SLC24A4 Antibody

Datasheet

Code	CSB-PA129178
Size	US$297
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Image	Western blot analysis of extracts from RAW264.7 cells, using SLC24A4 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC24A4 Polyclonal antibody

Uniprot No.

Q8NFF2

Target Names

SLC24A4

Alternative Names

Na(+)/K(+)/Ca(2+)-exchange protein 4 antibody; NCKX4 antibody; NCKX4_HUMAN antibody; SHEP6 antibody; SLC24A2 antibody; SLC24A4 antibody; Sodium/potassium/calcium exchanger 4 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 4 antibody; Solute carrier family 24 member 4 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from internal of Human SLC24A4.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis.

Gene References into Functions

no significant relation was noted between SLC24A4 rs10498633 and late-onset Alzheimer;s disease risk in neither apolipoprotein E (APOE) epsilon4 carriers nor non-carriers after adjusting for age and gender PMID: 27215332
pigment cells express robust, functional NCKX4 activity PMID: 27093457
mutations in SLC24A4 and SLC24A5 are responsible for the phenotypic defects observed in human amylogenesis imperfecta and non-syndromic oculocutaneous albinism patients. PMID: 27129268
The expressions of NCX1 and NCKX4 were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels. PMID: 25500693
enamel maturation is dependent upon STIM1 and SLC24A4 function, and that there are important differences in the Ca(2+) transcellular transport systems used by secretory- and maturation-stage ameloblasts. PMID: 24621671
Brain DNA methylation in sLC24A4 was associated with pathological Alzheimer disease. PMID: 25365775
These findings support a key role for SLC24A4 in calcium transport during enamel formation. PMID: 23375655
Taken together, these data demonstrate a potentially important role for NCX1 in control of Ca2+ homeostasis and link store depletion via STIM1 directly with NCX activation. PMID: 21126331
identification and sequencing, as well as mapping to chromosomal region 14q32 PMID: 12379639
IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation. PMID: 18483556

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Involvement in disease

Amelogenesis imperfecta, hypomaturation type, 2A5 (AI2A5)

Subcellular Location

Cytoplasm. Cell membrane; Multi-pass membrane protein.

Protein Families

Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily

Tissue Specificity

Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine.

Database Links

HGNC: 10978

OMIM: 210750

KEGG: hsa:123041

STRING: 9606.ENSP00000431840

UniGene: Hs.385530

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Gene Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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