SLC25A11 Antibody

Code CSB-PA269768
Size US$297
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  • Western blot analysis of extracts from HeLa cells, using SLC25A11 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC25A11 Polyclonal antibody
Uniprot No.
Target Names
SLC25A11
Alternative Names
SLC25A11; SLC20A4; Mitochondrial 2-oxoglutarate/malate carrier protein; OGCP; Solute carrier family 25 member 11
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human SLC25A11.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis. Acts as a tumor-suppressor gene implicated in the predisposition to metastatic paraganglioma.
Gene References into Functions
  1. The Network analyses identified SLC25A11expression in temporal cortex in patient with late-onset Alzheimer's disease. PMID: 28242297
  2. OGC as a model protein for understanding the transport mechanism of mitochondrial carriers. PMID: 23054077
  3. OGCP degrades through proteasome and lysosome degradation pathways. The degradation of parkin protein can promote the degradation of OGCP. PMID: 21500544
  4. Controlling MISC-1/OGC function allows regulation of mitochondrial morphology and cell survival decisions by the metabolic needs of the cell. PMID: 21448454
  5. data provide evidence for a role of the 2-oxoglutarate carrier as a glutathione transporting polypeptide PMID: 12939596
  6. porphyrin accumulation in mitochondria is mediated by OGC and porphyrins are able to competitively inhibit 2-oxoglutarate uptake into mitochondria PMID: 16920706

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Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
Mitochondrial carrier (TC 2.A.29) family
Database Links

HGNC: 10981

OMIM: 604165

KEGG: hsa:8402

STRING: 9606.ENSP00000225665

UniGene: Hs.184877

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