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SLC39A2 Antibody

Datasheet
Code CSB-PA009071
Size US$119
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Product Details

Uniprot No.
Q9NP94
Target Names
SLC39A2
Alternative Names
hZIP2 antibody; 6A1 antibody; Eti-1 antibody; Eti1 antibody; hZIP2 antibody; MGC119190 antibody; OTTHUMP00000164402 antibody; S39A2_HUMAN antibody; SLC39A2 antibody; Solute carrier family 39 (zinc transporter) member 2 antibody; Solute carrier family 39 member 2 antibody; Zinc transporter ZIP2 antibody; ZIP 2 antibody; ZIP-2 antibody; ZIP2 antibody; Zrt and Irt like protein 2 antibody; Zrt- and Irt-like protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the N-terminal region of Human ZIP2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Protocols
Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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SLC39A2 Proteins

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Target Background

Function
Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.
Gene References into Functions
  1. Results showed decreased expression of Zn uptake transporters ZIP2 and ZIP4 on mRNA and protein level correlating with SHANK3 expression levels, and found reduced levels of ZIP4 protein co-localizing with SHANK3 at the plasma membrane. ZIP4 exists in a complex with SHANK3. Further results confirmed a link between enterocytic SHANK3, ZIP2 and ZIP4. PMID: 28345660
  2. the splice switch to DeltaC-ZIP2 as well as decreased expression of other ZIPs caused zinc deficiency, which is sufficient for induction of MUC5AC. PMID: 29289532
  3. ZIP2 Gln/Arg/Leu polymorphism involve in proinflammatory mediation and zinc homeostasis in elderly population with a more pronounced anti-inflammatory effect of zinc supplementation in subjects carrying ZIP2 Leu- (Arg43Arg) genotype PMID: 26643924
  4. results of this study suggest that ZIP2, a zinc transporter expressed specifically in the epidermis, and zinc taken up by ZIP2 are necessary for the differentiation of keratinocytes PMID: 24936057
  5. Increased expression of Zip2 gene is closely associated with immunity of pulmonary tuberculosis patients, suggesting that the Zip2 gene may play a key role in initial infection control. PMID: 23686108
  6. Expression of two Zn2+ influx transporters, ZIP2 and ZIP4, is reduced as a function of retinal pigment epithelium age. PMID: 21603979
  7. regulation of ZIP2 protein in human breast cancer xenografts PMID: 17786585
  8. Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease. PMID: 18328005

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
ZIP transporter (TC 2.A.5) family
Tissue Specificity
Expressed only in prostate and uterine epithelial cells.
Database Links

HGNC: 17127

OMIM: 612166

KEGG: hsa:29986

STRING: 9606.ENSP00000298681

UniGene: Hs.175783

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