SLC39A5 Antibody

Code CSB-PA900358
Size US$166
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Image
  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hepg2 cells, Primary antibody: CSB-PA900358(SLC39A5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details

Uniprot No.
Target Names
SLC39A5
Alternative Names
SLC39A5; ZIP5; Zinc transporter ZIP5; Solute carrier family 39 member 5; Zrt- and Irt-like protein 5; ZIP-5
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human SLC39A5
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Seems to play a central role in controlling organismal zinc status. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Plays a role in eye development.
Gene References into Functions
  1. we found that downregulation of ZIP5 by RNA interference inhibited esophageal cancer growth in vivo, reduced the expression of COX2, and promoted the expression of E-cadherin. PMID: 27458102
  2. ZIP5 knockdown inhibited the proliferation, migration and invasion of ESCC and suppressed COX2, cyclin D1 and E-cadherin expression, which led to the inhibition of cell progression in esophageal squamous cell carcinoma . PMID: 26133979
  3. mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2. PMID: 25525168
  4. Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells PMID: 15322118
Involvement in disease
Myopia 24, autosomal dominant (MYP24)
Subcellular Location
Basolateral cell membrane; Multi-pass membrane protein.
Protein Families
ZIP transporter (TC 2.A.5) family
Tissue Specificity
Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney.
Database Links

HGNC: 20502

OMIM: 608730

KEGG: hsa:283375

STRING: 9606.ENSP00000266980

UniGene: Hs.591018

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