SLC9A3R2 Antibody

1. Studies support a role for NHERF-1 and NHERF-2 (Na+/H+ exchanger regulatory factors 1 and 2) in regulating the distribution of Group II metabotropic glutamate receptor (mGluRs) in the murine brain, while conversely the effects of the mGluR2/3 PDZ-binding motifs on receptor signaling are likely mediated by interactions with other PDZ scaffold proteins beyond the NHERF proteins. PMID: 28392297
2. Moreover, the S303D mutation enhances the in vivo dynamics of the E3KARP tail alone, whereas in vitro the interaction of E3KARP with active ezrin is unaffected by S303D PMID: 26310448
3. Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCdelta signaling. PMID: 24760985
4. Data indicate that the tails promote different microvillar localizations for EBP50 and E3KARP, which localized along the full length and to the base of microvilli, respectively. PMID: 23985317
5. NHERF2 domain was functionally significant in NHE3 regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3 PMID: 23612977
6. functional regulation of C3aR by NHERFs in human mast cells PMID: 23284683
7. AnxA2 and NHERF2 form a scaffold complex that links adjacent Tir molecules at the plasma membrane forming a lattice that could be involved in retention and dissemination of other effectors at the bacterial attachment site. PMID: 22587461
8. NHERF-2 is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling. PMID: 22343917
9. CaMKII inhibition of NHE3 reguires NHEF2. PMID: 22371496
10. Data show that both NHERF2 and NHERF1 are involved in setting NHE3 activity. PMID: 21191106
11. The results of this study revealed that NHERF-2 can interact with GLAST in astrocytes to enhance GLAST stability and activity. PMID: 20430067
12. WNK4 and NHERF2 synergistically regulate TRPV5 by enhancing its forward trafficking and increasing its stability at plasma membrane, respectively. PMID: 21187068
13. The authors generated a HeLa cell line stably expressing HA-tagged NHERF2 and found that Map, EspI and NleH1 colocalize and interact with intracellular NHERF2 via their C-terminal PDZ-binding motif. PMID: 20618342
14. Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells. PMID: 20663896
15. NHERF1 and NHERF2 exhibit isotype-specific effects on G protein activation. PMID: 20562104
16. Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes PMID: 11786550
17. E3KARP has a restricted tissue distribution with the highest expression being found in lung. It is largely colocalized with moesin and radixin, especially in the alveoli of the lung, as well as being highly enriched in the renal corpuscle. PMID: 11893083
18. Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. PMID: 12075354
19. A2BR binds to E3KARP upon agonist stimulation. PMID: 12080047
20. When the second PDZ domain of E3KARP is bound to down regulated in adenoma (dra) gene product, a structural link is built between the functionally coupled Na+/H+ and Cl-/HCO3- exchangers in the proximal colon. PMID: 12369822
21. NHERF2 and SGK1 interact to enhance ROMK1 activity by enhancing abundance of channel protein in cell membrane, allowing integration of genomic regulation and activation of SGK1 and NHERF2 in control of ROMK1 activity and renal K(+) excretion. PMID: 12444200
22. NHERF2, with ROMK1 and SGK1 has a role in regulating protein abundance in the plasma membrane and K(+) current PMID: 14623317
23. demonstration of the significance of SGK1 and NHERF2 as TRPV5 modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3 PMID: 15665527
24. the function of SIP-1/NHERF2 as an SRY cofactor during testis determination is conserved between human and mouse PMID: 16166090
25. analysis of NHERF recognition by ERM proteins PMID: 16615918
26. N-cadherin and beta-catenin play role in cell migration via PDGF-Rbeta-mediated signaling through the scaffolding molecule NHERF2 PMID: 17229887
27. While the presence of forskolin results in an increase in OCTN2 protein expression, the increase in uptake capacity may be compensated by the decreased expression of PDZK1, NHERF1 or NHERF2. PMID: 19091402

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HGNC: 11076

OMIM: 606553

KEGG: hsa:9351

STRING: 9606.ENSP00000408005

UniGene: Hs.440896