SMC4 Antibody

Datasheet

Code	CSB-PA885725YA01HU
Size	US$166
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Image	Immunohistochemistry analysis of human colon cancer using CSB-PA885725YA01HU at dilution of 1:100 Immunocytochemistry analysis of human kidney tissue using CSB-PA885725YA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA885725YA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SMC4 Polyclonal antibody

Uniprot No.

Q9NTJ3

Target Names

SMC4

Alternative Names

CAP C antibody; CAPC antibody; Chromosome associated polypeptide C antibody; Chromosome-associated polypeptide C antibody; hCAP C antibody; hCAP-C antibody; SMC 4 antibody; SMC protein 4 antibody; SMC-4 antibody; SMC4 antibody; SMC4_HUMAN antibody; SMC4L1 antibody; Structural maintenance of chromosomes 4 antibody; Structural maintenance of chromosomes 4 like 1 antibody; Structural maintenance of chromosomes protein 4 antibody; XCAP C homolog antibody; XCAP-C homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Structural maintenance of chromosomes protein 4 protein (406-501AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SMC4 Antibody (Product code: CSB-PA885725YA01HU) is Non-conjugated. For SMC4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA885725YB01HU	SMC4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA885725YC01HU	SMC4 Antibody, FITC conjugated
Biotin	CSB-PA885725YD01HU	SMC4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene References into Functions

analysis of functional differences of SMC2 and SMC4 hinge domain between condensins and cohesin in DNA recognition PMID: 26491021
Results indicate that miR-124-5p may target the tumorigenesis gene, SMC4, which suggests that expression levels of miR-124-5p in plasma and FFPE samples. PMID: 25081869
Knockdown of SMC-4 expression significantly suppressed the proliferation. PMID: 25422241
SMC4 expression was significantly associated with tumor size, de-differentiation, advanced stages and vascular invasion of the primary liver cancers. PMID: 22842912
mutation analysis of hCAP-C & hCAP-E in leukemia-lymphoma cell lines including 8 pyothorax-associated lymphoma (PAL); 3 of 8 PAL cell lines have hCAP-C or hCAP-E heterozygous mutations, indicating condensin mutations are relatively frequent in PAL PMID: 17488335

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Subcellular Location

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Protein Families

SMC family, SMC4 subfamily

Tissue Specificity

Widely expressed. Higher expression in testis, colon, thymus.

Database Links

HGNC: 14013

OMIM: 605575

KEGG: hsa:10051

STRING: 9606.ENSP00000341382

UniGene: Hs.58992

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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