SNX18 Antibody

Datasheet

Code	CSB-PA850423ESR1HU
Size	US$166
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Image	Western blot All lanes: SNX18 antibody at 1.6µg/ml Lane 1: A549 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Mouse kidney tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 69, 70, 65 kDa Observed band size: 69 kDa Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA850423ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA850423ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SNX18 Polyclonal antibody

Uniprot No.

Q96RF0

Target Names

SNX18

Alternative Names

FLJ11997 antibody; FLJ32560 antibody; FLJ61062 antibody; MGC150827 antibody; MGC150829 antibody; SH3 and PX domain containing protein 3B antibody; SH3 and PX domain-containing protein 3B antibody; SH3PX2 antibody; SH3PXD3B antibody; SNAG 1 antibody; SNAG1 antibody; SNX18 antibody; SNX18_HUMAN antibody; Sorting nexin 18 antibody; Sorting nexin associated golgi protein 1 antibody; Sorting nexin-18 antibody; Sorting nexin-associated Golgi protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Sorting nexin-18 protein (449-628AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A.

Gene References into Functions

SNX18 promotes autophagosome formation by virtue of its ability to remodel membranes and provide membrane to forming autophagosomes. PMID: 23878278
The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 and SNX33 - are required for progression and completion of mitosis. PMID: 22718350
FIP5-SNX18 complex plays a pivotal role in the polarized transport of apical proteins during apical lumen initiation in epithelial cells. PMID: 21969467
functions in multiple pathways of endocytosis at the plasma membrane PMID: 20427313
The results indicate that SNX9-family members make up discrete membrane-scission units together with dynamin, and suggest that SNX18 mediates budding of carriers for AP-1-positive endosomal trafficking. PMID: 18411244

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Subcellular Location

Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

Sorting nexin family

Database Links

HGNC: 19245

KEGG: hsa:112574

STRING: 9606.ENSP00000317332

UniGene: Hs.432755

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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