SOX7 Antibody

1. These results provide the first clue that miR-24-3p could play a role as an oncomiR in Lung cancer by regulating SOX7. PMID: 29231262
2. we have identified an array of potential target genes of SOX7 and examined four of them for their roles in SOX7-mediated tumor suppression. We found that SOX7 could both activate and repress its target genes; and achieve its antiproliferative function through regulating multiple genes simultaneously. PMID: 29757932
3. SOX7 transcription factor mediates PDGF-BB-induced IL-33 expression. PMID: 27150562
4. Mechanistically, SOX7 was confirmed to be the downstream target of miR-616 in NSCLC cells. Forced expression of SOX7 prevented the promoting effects of miR-616 overexpression on the proliferation and metastasis of NSCLC cells, while knockdown of SOX7 reversed the inhibitory effects of miR-616 knockdown on the proliferation and metastasis of NSCLC cells. PMID: 28765960
5. miR-9 was up-regulated and SOX7 was down-regulated in human non-small-cell lung cancer tissues and cell lines. PMID: 28266181
6. The results indicate that SOX7 may inhibit the progression of liver carcinoma and that SOX7 downregulation may accurately predict poor prognosis in liver carcinoma patients. PMID: 28586005
7. Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 and negatively with beta-catenin, suggesting that SOX7 and AXIN2 might play important roles as co-regulators through the Wnt-beta-catenin pathway in the breast tissue to affect the carcinogenesis process. PMID: 27188720
8. SOX7 inhibits oncogenic beta-catenin-mediated transcription by disrupting the beta-catenin/BCL9 interaction. PMID: 29271667
9. Overexpression of miR-935 inhibited SOX7 expression. PMID: 27697092
10. The results suggest that miR-664 functions as an oncogene miRNA and has an important role in promoting human osteosarcoma cell invasion and migration by suppressing SOX7 expression. PMID: 26515813
11. miR-595 played a critical role in carcinogenesis by suppression of SOX7. PMID: 27133048
12. Aberrant methylation of the promoter regions of the SOX7 gene in patients with acute myeloid leukemias. PMID: 27459612
13. miR-935 contributed to cell proliferation of gastric cancer through targeting SOX7. PMID: 27044823
14. the HMG-box is a key domain of SOX7 for negatively regulating the Wnt/beta-catenin signaling pathway when functioning as a tumor suppressor in a glioma. PMID: 26944317
15. The results provided unequivocal evidence for a novel tumor suppressor role of SOX7 in acute myeloid leukemia PMID: 25940713
16. SOX7 plays an important inhibitory role in hepatocarcinogenesis, and might be a novel target for hepatocellular carcinoma therapy. PMID: 24816720
17. Ectopic expression of miR-492 led to downregulation of SOX7 protein. PMID: 25407488
18. Low SOX7 expression is associated with hepatocellular carcinoma. PMID: 25073511
19. The expression of SOX7 correlates with tumor progression as a tumor suppressor, possibly through the Wnt/beta-catenin signaling pathway in ovarian cancers, suggesting that SOX7 may be a promising prognostic marker. PMID: 25297608
20. Decreased expression of Sox7 correlates with the upregulation of the Wnt/beta-catenin signaling pathway and the poor survival of gastric cancer patients. PMID: 24788044
21. miR-184 represents a potential onco-miR and plays an important role in HCC progression by suppressing SOX7 expression PMID: 24558429
22. SOX7 acts as a tumor suppressor in breast cancer. PMID: 24012678
23. SOX7 is a novel tumor suppressor gene silenced in the majority of NSCLC samples. PMID: 23557216
24. Sox7 is a negative regulator of Wnt/beta-catenin signaling pathway through impeding the transcriptional machinery of beta-catenin/TCF/LEF-1 transcriptional complex, and the loss of expression may be involved in the pathogenesis of endometrial cancer. PMID: 23295859
25. Association of SOX7 protein expression with clinical outcomes was evaluated. SOX7 mRNA expression was significantly down-regulated in lung adenocarcinoma compared with matched adjacent normal tissues. PMID: 22777918
26. The methylation of the CpG island of the SOX7 gene can be used as a predictive factor for the development and prognosis of myelodysplastic syndrome patients. PMID: 22706399
27. Data show that SOX7 is upregulated by aspirin and is involved in aspirin-mediated growth inhibition of human colorectal cancer SW480 cells. PMID: 22171135
28. stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 producing extraembryonic endoderm progenitors PMID: 18682240
29. Sox7 is a tumor suppressor that functions as an independent checkpoint for beta-catenin transcriptional activity. Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors. PMID: 18819930
30. stable expression induces a stable expandable extra embryonic endoderm phenotype in hESCs PMID: 18940723
31. SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. PMID: 19108950
32. gene expression, chromosome mapping, transactivation, interference with Wnt signaling PMID: 11691915

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HGNC: 18196

OMIM: 612202

KEGG: hsa:83595

STRING: 9606.ENSP00000301921

UniGene: Hs.709543