SRPX2 Antibody

Datasheet

Code	CSB-PA022690GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O60687

Target Names

SRPX2

Alternative Names

BPP antibody; CBPS antibody; PMGX antibody; RESDX antibody; SRPUL antibody; SRPX 2 antibody; SRPX2 antibody; SRPX2_HUMAN antibody; Sushi repeat containing protein SRPX2 antibody; Sushi repeat containing protein X linked 2 antibody; Sushi repeat protein antibody; Sushi repeat-containing protein SRPX2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human SRPX2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.

Gene References into Functions

SRPX2 potentially acts as an independent prognostic predictor and a drug-target for hepatocellular carcinoma patients. PMID: 28654796
Increased Sushi repeat-containing protein X-linked 2 is associated with progression of colorectal cancer. PMID: 25737434
In rolandic epilepsy patients no major role was found for an association with SRPX2 or ELP4 genes. PMID: 24995671
High SRPX2 expression is associated with gastric cancer. PMID: 24700475
SRPX2 is an epilepsy- and language-associated gene that is a target of the foxhead box protein P2 (FoxP2) transcription factor. PMID: 24179158
The SRPX2 protein contains the P-DUDES structural domain in its C-terminal region. This domain has significant albeit remote sequence similarity to thioredoxin-like domains, and is predicted to possess an oxidoreductase function. PMID: 209648
Hypomethylation of SRPX2 appeared at the transition from adenoma to carcinoma, and was correlated with adenocarcinoma histology, microsatellite stability, and poor differentiation. PMID: 23115050
SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer cells. PMID: 22242148
The FOXP2-SRPX2/uPAR network provides exciting insights into molecular pathways underlying speech-related disorders. PMID: 20858596
acts as regulator of ICAM1 and E-selectin during endotoxemia PMID: 20236627
These findings suggest that Srpx2 regulates endothelial cell migration and tube formation and provides a new target for modulating angiogenesis. PMID: 19667118
The involvement of SRPX2 in these disorders suggests an important role for SRPX2 in the perisylvian region critical for language and cognitive development. PMID: 16497722
The R75K human-specific variation occurred in an important functional loop of the first sushi domain of SRPX2, indicating that this evolutionary mutation may have functional importance PMID: 17942002
Interaction of SRPX2 with uPAR involved in the functioning, the development and disorders of the speech cortex. PMID: 18718938
the biological functions of SRPX2 include cellular migration and adhesion to cancer cells. PMID: 19065654

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Involvement in disease

Rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX)

Subcellular Location

Secreted. Cytoplasm. Cell surface. Cell junction, synapse.

Tissue Specificity

Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed

Database Links

HGNC: 30668

OMIM: 300642

KEGG: hsa:27286

STRING: 9606.ENSP00000362095

UniGene: Hs.306339

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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