SRSF6 Antibody

1. Data suggest that regulation of pancreatic beta-cell function and survival/apoptosis involves alternative splicing modulated by key splicing regulator SRP55; SRP55-regulated alternative splicing includes modulation of function of pro-apoptotic proteins (BIM, BAX), JNK signaling, and endoplasmic reticulum stress. (BIM = BCL-2 interacting protein BIM; BAX = apoptosis regulator BAX) PMID: 29246973
2. The recent studies suggest that correcting the SRSF6-driven missplicing and/or microtubule-associated imbalance might be of therapeutic value in Huntington's disease. PMID: 27529534
3. LINC01133 inhibits epithelial mesenchymal transformation and metastasis in colorectal neoplasms by directly binding to SRSF6 as a target mimic. PMID: 27443606
4. SRSF6 is a regulator of wound healing and tissue homeostasis in skin. PMID: 24440982
5. Zinc inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS. PMID: 23648111
6. The splicing factor SRSF6 is an oncoprotein that regulates the proliferation and survival of lung and colon cancer cells. PMID: 23132731
7. Phosphorylation of SRp55 by Dyrk1A suppressed its ability to promote Tau exon 10 inclusion. PMID: 22767602
8. Report upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors. PMID: 22516966
9. SRp55 aids in the generation of partially spliced and unspliced HIV-1 mRNAs. PMID: 21345357
10. interacts with calcitonin/CGRP exon 4 exonic splice enhancer(ESE); binding of SRp55 to an ESE required for calcitonin mRNA splicing suggests that the different levels of SRp55 in different cell types may regulate calcitonin/CGRP alternative splicing PMID: 12531473
11. SRp55 binding to a suboptimal RNA binding site in the calcitonin/CGRP pre-mRNA exonic splice enhancer, or increasing the amount of SRp55 in cells, is required for calcitonin mRNA production. PMID: 12549914
12. Higher relative expression of SR55 protein in breast tumors was associated with altered pattern of CD44 variants incorporating exon v7 PMID: 12779084
13. These findings show that modulation of splicing activity in p53-deficient cells during the early response to sub-lethal DNA damage results in a change in the splicing of target genes, thus modifying the cellular response to genotoxic agents. PMID: 18571879

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HGNC: 10788

OMIM: 601944

KEGG: hsa:6431

STRING: 9606.ENSP00000244020

UniGene: Hs.684950