ST6GALNAC2 Antibody

1. MicroRNAs miR-135b and miR-182 may reverse the resistance to 5-fluorouracil (5-FU) in colorectal cancer (CRC) cells by targeting ST6GALNAC2 via PI3K/AKT pathway, which render potential chemotherapy targets for the treatment of CRC. PMID: 28767179
2. miR-182/-135b/ST6GALNAC2/PI3K/AKT axis could function as regulator of progression in colorectal cancer PMID: 29030743
3. Study provides evidence that mutations in B3GNT2, B4GALT2, and ST6GALNAC2 underlie aberrant glycosylation, and contribute to the pathogenesis of molecular subsets of colon and other gastrointestinal malignancies. PMID: 27004849
4. Results provide evidence that ST6GalNAcII activated the invasion in follicular thyroid cancer cells through regulating the activity of PI3K/Akt pathway. PMID: 26820593
5. High expression level of ST6GalNAcII is associated with invasive phenotype of breast cancer. PMID: 24756995
6. ST6GalNAc II might be participated in the glycosylation of Axl, and this Axl glycosylation may mediate the tumorigenicity, invasion, and distant metastasis of breast phyllodes tumor cells. PMID: 24961352
7. Results identified the sialyltransferase ST6GalNAc2 as a novel breast cancer metastasis suppressor. PMID: 24520024
8. Il-6 and Il-4 reduced galactosylation of the O-glycan substrate directly via decreased expression of the galactosyltransferase C1GalT1 and, indirectly, via increased expression of the sialyltransferase ST6GalNAc-II PMID: 24398680
9. ST6GalNAc2 is a novel enzyme that regulates leukocyte adhesion under fluid shear PMID: 23548905
10. Expression of the ST6-GalNAcII gene and activity of the CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in immunoglobulinA1-producing cell lines. PMID: 17418236
11. the ADG haplotype in the ST6GALNAC2 gene is a functional regulatory variant that may contribute to the genetic susceptibility in a subset of patients in whom the desialylation of IgA1 molecules was the main causative pathogenesis of IgAN PMID: 17480010
12. reduced sialylation of serum IgA1 may result from decreased expression of ST6GALNAC2. PMID: 19170967
13. potential genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgA nephropathy PMID: 19357720

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HGNC: 10867

OMIM: 610137

KEGG: hsa:10610

STRING: 9606.ENSP00000225276

UniGene: Hs.592105