STK38 Antibody

1. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. PMID: 30018336
2. Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1. PMID: 28216640
3. Data show that STK38 supports Ras-driven transformation through promoting detachment-induced autophagy. PMID: 27283898
4. a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling PMID: 23840619
5. Data establish STK38 as a conserved regulator of autophagy in human cells and flies. PMID: 26387716
6. PLK1-mediated phosphorylation protects the binding of Mob1 to NDR1 and subsequent NDR1 activation PMID: 26057687
7. STK38-mediated phosphorylation of CDC25A at Ser-76 and the subsequent degradation of CDC25A are required to promote DNA damage-induced G2/M checkpoint activation. PMID: 25936524
8. STK38 regulates MYC protein stability and turnover in a kinase activity-dependent manner. STK38 kinase inactivation abrogates apoptosis following B-cell receptor activation, whereas its silencing significantly decreases MYC levels and increases apoptosis. PMID: 23178486
9. cyclin D1 has a role in promoting cell cycle progression by enhancing NDR1/2 kinase activity independent of Cdk4 PMID: 23897809
10. 17-allylamino-17-demethoxygeldanamycin down-regulates STK38, modulating radiosensitivity. PMID: 23886587
11. Findings suggest a function of NDR1, which may regulate NF-kappaB activation by its kinase activity. PMID: 22674419
12. GSK-3beta inhibits full activation of STK38, and STK38 activation is required to prevent cell death in response to oxidative stress PMID: 22142472
13. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. PMID: 21730291
14. These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells. PMID: 21262772
15. Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings. PMID: 20624913
16. NDR1 and NDR2 serine-threonine kinases are regulated by mob proteins PMID: 15067004
17. an insert within the catalytic domain between subdomains VII and VIII is autoinhibitory, and the binding of human MOB1 to the N-terminal domain of NDR induces the release of this autoinhibition. PMID: 15197186
18. The NDR1 and NDR2 kinases were incorporated into HIV-1 particles and were cleaved by the HIV-1 protease. PMID: 15582665
19. In vivo activation of human NDR by membrane-bound hMOBs is dependent on their interaction and occurs solely at the membrane. PMID: 16135814
20. These data indicate that NDR-driven centrosome duplication requires Cdk2 activity and that Cdk2-induced centrosome amplification is affected upon reduction of NDR activity. PMID: 17317633
21. phosphorylation of MOB1 at Thr74 by MST2 is essential to make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1 PMID: 18362890

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HGNC: 17847

OMIM: 606964

KEGG: hsa:11329

STRING: 9606.ENSP00000229812

UniGene: Hs.409578