STXBP4 Antibody

Datasheet

Code	CSB-PA757971ESR2HU
Size	US$166
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Image	Western blot All lanes: STXBP4 antibody at 10μg/ml + PC-3 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 62, 27 kDa Observed band size: 62 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) STXBP4 Polyclonal antibody

Uniprot No.

Q6ZWJ1

Target Names

STXBP4

Alternative Names

FLJ16496 antibody; MGC149829 antibody; MGC50337 antibody; OTTHUMP00000082667 antibody; OTTHUMP00000227400 antibody; STX4-interacting protein antibody; STXB4_HUMAN antibody; Stxbp4 antibody; Synip antibody; Syntaxin 4 interacting protein antibody; Syntaxin 4-interacting protein antibody; Syntaxin binding protein 4 antibody; Syntaxin-binding protein 4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Syntaxin-binding protein 4 protein (344-553AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.

Gene References into Functions

High STXBP4 expression is associated with squamous cell carcinogenesis. PMID: 29735662
The deleterious SNPs localized in STXBP4 and ZNF404 genes were identified which might play a role in breast cancer development by dysregulating its gene expression. PMID: 28422318
Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus. PMID: 27600471
Whole transcriptome sequencing followed by pathway analysis indicated that STXBP4 is involved in functional gene networks that regulate cell growth, proliferation, cell death, and survival in cancer. Platelet-derived growth factor receptor alpha (PDGFRalpha) was a key downstream mediator of STXBP4 function. In line with this, shRNA mediated STXBP4 and PDGFRA knockdown suppressed tumor growth in soft-agar and xenograft ... PMID: 28087642
meta-analysis suggested that polymorphism STXBP4/COX11 rs6504950 variant was significantly associated with breast cancer risk; the A allele of rs6504950 decreased the risk of breast cancer PMID: 22863968
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20416077
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20095854
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20145138
Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cells PMID: 12855681
Stxbp4 and RACK1, two scaffold proteins, play central roles in balancing DeltaNp63 protein levels. While Stxbp4 functions to stabilize DeltaNp63 proteins, RACK1 targets DeltaNp63 for degradation. PMID: 19451233

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Subcellular Location

Cytoplasm.

Database Links

HGNC: 19694

OMIM: 610415

KEGG: hsa:252983

STRING: 9606.ENSP00000365530

UniGene: Hs.35199

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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