SYNPO Antibody

1. The postsynaptic protein, synaptopodin (SYNPO) was significantly down-regulated in both dementia with Lewy bodies and Parkinson's disease dementia subgroups, suggesting a defective synaptic transmission in the demented patients. PMID: 28800743
2. Urine synaptopodin is associated with serum creatinine elevation in the patients with glomerulonephritis including diabetic kidney disease regardless of urine albumin excretion. We suggest that the urine synaptopodin level can predict glomerular damage independently of the urine albumin excretion. PMID: 27604800
3. SYNPO variants are involved in AMPA receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility. PMID: 26405221
4. This study identified and confirmed SYNPO protein changes within the postsynaptic density in schizophrenia PMID: 25048004
5. Case Report: immunohistologically detected synaptopodin upregulation in foamy podocytes in Fabry disease due to novel alpha-galactosidase A mutation. PMID: 25295576
6. expression significantly down-regulated in presence of WT1 R458Q mutation PMID: 25145932
7. Shear stress induced actin binding proteins including SYNPO may play a critical role in endothelial wound healing. PMID: 24561195
8. These results suggested that the SA is an important component of the molecular machinery controlling the calcium-dependent accumulation of AMPA-receptors (AMPA-R) at excitatory synapses. [review] PMID: 22217474
9. The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy. PMID: 21655212
10. Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments. PMID: 20630939
11. Heterozygous mutations in the promoters of the ACTN4 and SYNPO genes are found in patients with idiopathic focal segmental glomerulosclerosis. PMID: 19666657
12. interaction with tight junction protein MAGI-1 PMID: 12042308
13. Our data suggest dendritic spine accumulation of SYNPO critically depends on interaction with postsynaptic alpha-actinin and that SYNPO may regulate spine morphology, motility and function via its distinct modes of association with the actin cytoskeleton. PMID: 15659229
14. Synaptopodin, an actin-associated protein, as a novel regulator of RhoA signalling and cell migration in kidney podocytes. PMID: 16622418
15. We conclude that down-regulation of nephrin and synaptopodin is associated with proteinuria in women with preeclampsia. PMID: 17255128
16. Discusses isoforms of mouse Synpo, two of which are consistent with those found in human. PMID: 15841212

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HGNC: 30672

OMIM: 608155

KEGG: hsa:11346

STRING: 9606.ENSP00000377789

UniGene: Hs.435228