TFAP4 Antibody

1. these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment. PMID: 28981098
2. Results show that AP4 is overexpressed in primary carcinoma compared with the non-cancerous mucosa and is up-regulated in EMT in colorectal cancer (CRC) cells. Its overexpression is correlated with liver metastasis in CRC and poor outcome. Also, The study show that USP22 binds to the promoter region of AP4 to activate its transcription. PMID: 28427243
3. Data show that transcription factor activating enhancer binding protein-4 (TFAP4) is a direct transcriptional target of MYCN in neuroblastoma and that high levels of this transcription factor are associated with poor clinical outcome in this disease. PMID: 27448979
4. Depletion of either Arl5b or AP4 results in the accumulation of APP. PMID: 28000370
5. results indicate that AP4 is a central mediator and coordinator of cell cycle progression PMID: 25261373
6. the 16 SNP variants studied in the genes encoding the four units of AP-4 do not have a major role in overall CP, but SNP rs1217401 of AP4B1 is significantly associated with the risk of CP as a sequela of neonatal HIE in the Chinese population. PMID: 24065543
7. betaTrCP-dependent degradation of TFAP4 is required for the fidelity of mitotic division PMID: 24500709
8. Senescence caused by AP4-deficiency was prevented by depletion of p16 and/or p21, demonstrating that these factors mediate senescence caused by AP4 loss. PMID: 23949224
9. Elevated AP4 expression in primary colorectal cancer (CRC) significantly correlated with liver metastasis and poor patient survival. Findings imply AP4 as a new regulator of epithelial-mesenchymal transition that contributes to metastatic processes in CRC PMID: 23752226
10. findings provide evidence that a high expression level of AP-4 serves as a biomarker for poor prognosis for hepatocellular carcinoma PMID: 23055200
11. The expression of AP-4 was silenced by the siRNAs transfection. PMID: 22615908
12. Overexpression of AP-4 is associated with gastric carcinoma. PMID: 21336989
13. in serum- or IGF-1-stimulated breast cancer MCF-7 cells, JNK induces SHP1 expression through the binding of AP-4 and RFX-1 transcription factors to the epithelial tissue-specific SHP1 promoter. PMID: 21719561
14. Activator protein-4 expression was associated with the expression of matrix metalloproteinase-9 and vascular endothelial growth factor in the advanced colorectal cancer. PMID: 18480385
15. Docking studies showed that the ATF4 DpSGIXXpSXE motif fits the binding pocket of beta-TrCP through an S-turning conformation. PMID: 18052253
16. c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. PMID: 18818310
17. AP-4 participates in a transcriptional-regulating complex at the HDM2-P2 promoter in response to DNA damage. PMID: 19505873

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HGNC: 11745

OMIM: 600743

KEGG: hsa:7023

STRING: 9606.ENSP00000204517

UniGene: Hs.513305