TGFBRAP1 Antibody

Datasheet

Code	CSB-PA819888LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA819888LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TGFBRAP1 Polyclonal antibody

Uniprot No.

Q8WUH2

Target Names

TGFBRAP1

Alternative Names

TGFBRAP1 antibody; Transforming growth factor-beta receptor-associated protein 1 antibody; TGF-beta receptor-associated protein 1 antibody; TRAP-1 antibody; TRAP1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Transforming growth factor-beta receptor-associated protein 1 protein (401-600AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TGFBRAP1 Antibody (Product code: CSB-PA819888LA01HU) is Non-conjugated. For TGFBRAP1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA819888LB01HU	TGFBRAP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA819888LC01HU	TGFBRAP1 Antibody, FITC conjugated
Biotin	CSB-PA819888LD01HU	TGFBRAP1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo.

Gene References into Functions

Vps3 and Vps8 are required for recycling of beta1 integrins. PMID: 29476049
MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC. PMID: 27301951
the association of rs2679860 polymorphisms of TGFBRAP1 and DBP variation as well as plasma levels of TGF-beta1 PMID: 25856002
In the absence of Langerhans cells (LC), contact hypersensitivity (CHS) reactions in langerin-positive dendritic cell-specific TGF-betaR1-deficient mice are diminished, providing further evidence against a regulatory role for LC in CHS. PMID: 21998450

Subcellular Location

Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling.

Protein Families

TRAP1 family

Database Links

HGNC: 16836

OMIM: 606237

KEGG: hsa:9392

STRING: 9606.ENSP00000258449

UniGene: Hs.446350

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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