TIPRL Antibody

Code CSB-PA023569LA01HU
Size US$166
Order now
The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TIPRL Polyclonal antibody
Uniprot No.
Target Names
TIPRL
Alternative Names
1810011K17Rik antibody; dJ69E11.3 antibody; MGC3794 antibody; Putative MAPK activating protein PM10 antibody; Putative MAPK-activating protein PM10 antibody; RP1-69E11.1 antibody; Tip antibody; TIP41 antibody; TIP41-like protein antibody; tiprl antibody; TIPRL_HUMAN antibody; TOR signaling pathway regulator antibody; TOR Signaling Pathway Regulator like antibody; Type 2A-interacting protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TIP41-like protein (1-178AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TIPRL Antibody (Product code: CSB-PA023569LA01HU) is Non-conjugated. For TIPRL Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA023569LB01HU TIPRL Antibody, HRP conjugated ELISA
FITC CSB-PA023569LC01HU TIPRL Antibody, FITC conjugated
Biotin CSB-PA023569LD01HU TIPRL Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Gene References into Functions
  1. overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation PMID: 26717153
  2. Unlike yeast TIP41, TIPRL has a positive effect on mTORC1 signaling through the association with PP2Ac. PMID: 23892082
  3. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
  4. TIPRL is highly up-regulated in human HCC samples and cell lines, compared with noncancerous liver tissues. PMID: 22841785
  5. Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
  6. Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610

Show More

Hide All

Subcellular Location
Cytoplasm.
Protein Families
TIP41 family
Database Links

HGNC: 30231

OMIM: 611807

KEGG: hsa:261726

STRING: 9606.ENSP00000356807

UniGene: Hs.209431

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*