TMOD3 Antibody

Code CSB-PA023911GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TMOD3
Alternative Names
OTTHUMP00000162615 antibody; Tmod3 antibody; TMOD3_HUMAN antibody; Tropomodulin 3 (ubiquitous) antibody; Tropomodulin 3 ubiquitous antibody; Tropomodulin-3 antibody; U Tmod antibody; U-Tmod antibody; Ubiquitous tropomodulin antibody; UTmod antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TMOD3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.
Gene References into Functions
  1. study has identified several new proteins like RHOC, DLG5, UGDH, TMOD3 in addition to known chemoresistance associated proteins in non-small cell lung carcinoma. PMID: 26898345
  2. investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TMOD3, tropomyosin 3, and stomatin-like protein 2 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified. PMID: 22158085
  3. capping of actin filament pointed ends by Tmod3 inhibits cell migration and reveal a novel control mechanism for regulation of actin filaments in lamellipodia. PMID: 12707310
  4. levels of TM1, TM2 and TM3 are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase-signaling pathway PMID: 15095301
  5. the Tmod3 isoform may regulate actin dynamics differently in cells than the previously described tropomodulin isoforms PMID: 17012745
  6. findings show that the pointed-end capping protein Tmod3 contributes to epithelial cell shape within confluent monolayers of polarized epithelial cells PMID: 17928307

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Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Tropomodulin family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 11873

OMIM: 605112

KEGG: hsa:29766

STRING: 9606.ENSP00000308753

UniGene: Hs.4998

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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