TRIM44 Antibody

1. The levels of TRIM44 protein and TRIM44 mRNA in squamous cell carcinoma are both lowly expressed which is strongly associated with tumor staging, metastasis, and poor survival. PMID: 30383661
2. Elevated TRIM44 expression promotes human esophageal cancer development by epithelial mesenchymal transition via the AKT/mTOR pathway. PMID: 30098109
3. that TRIM44 predicts the risk of development and prognosis of endometrial cancer, highlighting its potential application as a therapeutic target for this malignancy PMID: 29526558
4. Silencing of TRIM44 inhibits the proliferation, migration and invasion of papillary thyroid cancer cells. PMID: 28965013
5. Mechanistic studies showed that knockdown of TRIM44 significantly reduced the levels of phosphorylated PI3K and Akt in PC-3 cells. Study provided evidence that knockdown of TRIM44 inhibited proliferation and invasion in prostate cancer cells, at least in part, through the inactivation of the PI3K/Akt signaling pathway. PMID: 28160462
6. the TRIM44 status was an independent prognostic factor for distant disease-free survival (p = 0.005) and overall survival (p = 0.002) of patients. PMID: 28885545
7. Data show that the TRIM44-mTOR axis increases metastasis and proliferation. PMID: 27058415
8. These results suggest that tripartite motif-containing protein 44 protein could play a crucial role in tumor invasion through its overexpression and highlight its usefulness as a predictor and potential therapeutic target in esophageal squamous cell carcinoma PMID: 28618928
9. results suggest that high expression of TRIM44 is associated with poor prognosis and that TRIM44 plays significant role in cell proliferation, migration, and anti-apoptosis in testicular germ cell tumor PMID: 27754579
10. High expression of TRIM44 is associated with enhanced cell proliferation, migration, invasion, and resistance to doxorubicin in hepatocellular carcinoma. PMID: 27619678
11. Variants in TRIM44 Cause Aniridia by Impairing PAX6 Expression PMID: 26394807
12. Trim44 promotes non-small cell lung cancer development through activation of NF-kappaB signaling via upregulating CXCL16 and MMP9 expression. PMID: 25345539
13. rim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA. PMID: 23460740
14. Overexpression of the TRIM44 protein was significantly correlated with an advanced type of macroscopic appearance. PMID: 22862969
15. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein. PMID: 19358823

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HGNC: 19016

OMIM: 612298

KEGG: hsa:54765

STRING: 9606.ENSP00000299413

UniGene: Hs.192103