TRIM62 Antibody

Datasheet

Code	CSB-PA559643
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA559643(TRIM62 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA559643(TRIM62 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 cells, hepg2 cells, Primary antibody: CSB-PA559643(TRIM62 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9BVG3

Target Names

TRIM62

Alternative Names

6330414G21Rik antibody; AI450348 antibody; DEAR1 antibody; ductal epithelium-associated RING Chromosome 1 antibody; E3 ubiquitin-protein ligase TRIM62 antibody; FLJ10759 antibody; FLJ16558 antibody; MGC115263 antibody; TRI62_HUMAN antibody; TRIM62 antibody; Tripartite motif containing 62 antibody; Tripartite motif-containing protein 62 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human TRIM62

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways. E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.

Gene References into Functions

Results found that TRIM62 was frequently down-regulated in both human cervical cancer (CC) cells and tissues. Low expression of TRIM62 in CC tissues was associated with aggressive clinicopathological features of CC patients. Its overexpression inhibits proliferation, migration and invasion of cervical cancer cells. PMID: 27793172
TRIM62 is a CARD9-binding partner. TRIM62 facilitated K27-linked poly-ubiquitination of CARD9. PMID: 26488816
Low TRIM62 levels, consistent with a tumor suppressor role, represent an independent adverse prognostic factor in AML. PMID: 25248926
DEAR1 is important in the regulation of the breast tumor microenvironment, polarity, and epithelial-mesenchymal transition. [Review] PMID: 25261235
results provide compelling evidence that DEAR1 is a critical tumor suppressor involved in multiple human cancers and provide a novel paradigm for regulation of TGF-beta-induced EMT through DEAR1's regulation of SMAD3 protein levels PMID: 23838884
these data indicate that TRIM62, a cytoplasmic protein, is a RING finger domain-dependent E3 ubiquitin ligase that catalyzes self-ubiquitination both in vitro and in vivo. PMID: 23402750
DEAR1 is a predictive biomarker for early onset breast cancer. PMID: 19536324
The evidence for the genetic alteration and loss of expression of DEAR1 in breast cancer and for the functional role of DEAR1 in the dominant regulation of acinar morphogenesis in 3D culture PMID: 19536326

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Subcellular Location

Cytoplasm.

Protein Families

TRIM/RBCC family

Database Links

HGNC: 25574

KEGG: hsa:55223

STRING: 9606.ENSP00000291416

UniGene: Hs.656006

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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