TRIM9 Antibody

Code CSB-PA880153LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA880153LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRIM9 Polyclonal antibody
Uniprot No.
Target Names
TRIM9
Alternative Names
TRIM9 antibody; KIAA0282 antibody; RNF91 antibody; E3 ubiquitin-protein ligase TRIM9 antibody; EC 2.3.2.27 antibody; RING finger protein 91 antibody; RING-type E3 ubiquitin transferase TRIM9 antibody; Tripartite motif-containing protein 9 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase TRIM9 protein (1-550AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TRIM9 Antibody (Product code: CSB-PA880153LA01HU) is Non-conjugated. For TRIM9 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA880153LB01HU TRIM9 Antibody, HRP conjugated ELISA
FITC CSB-PA880153LC01HU TRIM9 Antibody, FITC conjugated
Biotin CSB-PA880153LD01HU TRIM9 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
Gene References into Functions
  1. TRIM9s undergoes Lys-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1, leading to the activation of IRF3 signaling. PMID: 26915459
  2. Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK. PMID: 28701345
  3. TRIM9 is a brain-specific negative regulator of the NF-kappaB pro-inflammatory signalling pathway. PMID: 25190485
  4. These results suggest that TRIM9 plays an important role in the regulation of neuronal functions and participates in pathological process of Lewy body disease through its ligase activity. PMID: 20085810
Subcellular Location
Cytoplasm. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse. Cytoplasm, cytoskeleton.
Protein Families
TRIM/RBCC family
Tissue Specificity
Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies.
Database Links

HGNC: 16288

OMIM: 606555

KEGG: hsa:114088

STRING: 9606.ENSP00000298355

UniGene: Hs.654750

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