TRIP6 Antibody

1. Taken together, these findings showed that TRIP6 plays an important role in promoting HCC cells proliferation and may serve as a novel prognostic biomarker and therapeutic target in HCC. PMID: 29080747
2. TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma PMID: 26298725
3. the Trip6-GRIP1-myosin VI interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis PMID: 25673849
4. TRIP6 acts, in contrast to Zyxin, as an oncogene that partially accounts for the autonomous migratory, invasive and proliferative properties of Ewing's sarcoma cells. PMID: 24033704
5. TRIP6 overexpression promotes migration, invasion, and clonogenicity of Ewing's sarcoma cells PMID: 24033704
6. TRIP6 is involved in the regulation of nasopharyngeal carcinoma cell motility, and phosphorylation of tyrosine 55 residue plays an important regulatory role for this event PMID: 23576104
7. TRIP6 also promotes serum-induced reduction of nuclear p27(KIP1) expression levels. PMID: 23339869
8. High TRIP6 expression is associated with malignant pleural mesothelioma. PMID: 23313295
9. TRIP6 is engaged in cell proliferation, differentiation, transcription regulation and contributes to genome stability. [Review] PMID: 22054418
10. TRIP6 is a nucleocytoplasmatic shuttle protein essential for the coordination of focal adhesion dynamics and transcriptional responses in lysophosphosphatidic (LPA) and NF-kappaB signaling. PMID: 22054418
11. TRIP6 is an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. (Review) PMID: 21689746
12. TRIP6 promotes Fas-mediated cell migration in apoptosis-resistant glioma cells. This effect is regulated via the Src-dependent phosphorylation of TRIP6 at Tyr-55. PMID: 20876301
13. the OIP-1 c-peptide is the functional domain of OIP-1 PMID: 11771657
14. TRIP6 functions at a point of convergence between the activated LPA(2) receptor and downstream signals involved in cell adhesion and migration PMID: 14688263
15. ZRP-1 has a role in endoglin regulation of cytoskeletal organization PMID: 15148318
16. The data establish a physical and functional association between TRIP6 and RIP2, and suggest that RIP2's involvement in multiple NF-kappaB and ERK activation pathways is mediated through TRIP6. PMID: 15657077
17. Binding of LPP and TRIP6 to Scrib links Scrib to a communication pathway between cell-cell contacts and the nucleus, and implicates these zyxin family members in Scrib-associated functions. PMID: 16137684
18. The TRIP6 knock-down led to an increased number of longer stress fibers and to the induction of locomotive phenotype in carcinoma cells. PMID: 16240724
19. AMPK phosphorylated TRIP6 in vitro at the N-terminus and the transcriptional co-activator properties of TRIP6 were enhanced by AMPK action. PMID: 16624523
20. ZRP-1 plays a crucial role in coupling the cell-matrix/cell-cell-contact signals with Rho GTPase-mediated actin remodeling by localizing at cell-matrix and cell-cell contact sites. PMID: 17652164
21. OIP-1 inhibits measles virus nucleocapsid protein induced pagetic osteoclast formation/activity through suppression of RANK signaling PMID: 18348201
22. TRIP6 overexpression in colon tumors suggests its critical role in cancer progression. PMID: 19017743
23. IL-12 stimulates the OIP-1 gene expression through STAT-3 activation in CD4+ T cells. PMID: 19259951
24. Analysis of the subcellular distribution of ZRP-1 demonstrated that in the absence of endoglin, ZRP-1 mainly localizes to focal adhesion sites, whereas in the presence of endoglin ZRP-1 is found along actin stress fibers. PMID: 15148318

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HGNC: 12311

OMIM: 602933

KEGG: hsa:7205

STRING: 9606.ENSP00000200457

UniGene: Hs.534360